Recent advances in stem cell-based blastocyst models.
Recent advances in stem cell-based blastocyst models.
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DOI：
10.1016/j.gde.2023.102088
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发表时间：
2023-07
影响因子：
4
通讯作者：
Seiya Oura;James N Hamilton;Jun Wu
中科院分区：
文献类型：
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作者：
Seiya Oura;James N Hamilton;Jun Wu
早期胚胎发育是一个高度动态的过程，在决定生物体的健康和特征方面起着至关重要的作用。多年来，代表不同发育阶段的胚胎和胚外干细胞系一直是研究早期胚胎发生的有价值的模型。随着我们对干细胞培养和胚胎发育的理解不断深入，研究人员已经能够创造出更复杂的3D结构来模仿早期胚胎，例如囊胚样结构（类囊胚）。这些创新模式代表了该领域的重大飞跃。在这篇简短的综述中，我们将讨论基于干细胞的胚胎模型的最新进展，探索潜在的未来方向，并研究这些模型如何有助于更深入地了解早期哺乳动物发育。
Early embryo development is a highly dynamic process that plays a crucial role in determining the health and characteristics of an organism. For many years, embryonic and extraembryonic stem cell lines representing various developmental stages have served as valuable models for studying early embryogenesis. As our understanding of stem cell culture and embryo development has advanced, researchers have been able to create more sophisticated 3D structures mimicking early embryos, such as blastocyst-like structures (blastoids). These innovative models represent a significant leap forward in the field. In this mini-review, we will discuss the latest progress in stem cell-based embryo models, explore potential future directions, and examine how these models contribute to a deeper understanding of early mammalian development.