Improving Corrosion Resistance and Biocompatibility of Magnesium Alloy by Sodium Hydroxide and Hydrofluoric Acid Treatments
Improving Corrosion Resistance and Biocompatibility of Magnesium Alloy by Sodium Hydroxide and Hydrofluoric Acid Treatments
复制标题
通过氢氧化钠和氢氟酸处理提高镁合金的耐腐蚀性和生物相容性
DOI：
10.3390/app7010033
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发表时间：
2017-01-01
影响因子：
2.7
通讯作者：
Ding, Hong-Yan
中科院分区：
文献类型：
--
作者：
Pan, Chang-Jiang;Pang, Li-Qun;Ding, Hong-Yan
镁合金具有优异的力学性能和生物降解性，在心血管支架、骨移植等临时植入物方面得到了广泛的研究，但其在生理环境中的快速生物降解和有限的表面生物相容性阻碍了其临床应用。为了提高镁合金的耐腐蚀性和生物相容性，分别用氢氧化钠(NaOH)和氟化氢(HF)溶液对镁合金进行了化学转化层处理。衰减全反射傅里叶变换红外光谱(ATR-FTIR)和X射线光电子能谱(XPS)结果表明，成功地制备了氢氧化镁或氟化镁的化学转化层。氢氧化钠处理能显着提高表面亲水性，氟化氢处理提高了表面疏水性。两种化学转化层均能明显提高原始镁合金的耐蚀性。由于氟化镁的疏水性，经过氢氟化氢处理的镁合金表现出比经氢氧化钠处理的镁合金更好的耐蚀性。根据溶血试验和血小板粘附性的结果，表面化学修饰的样品与未修饰的镁合金相比，具有更好的血液相容性。此外，化学表面修饰的样品改善了与内皮细胞的细胞相容性，细胞在修饰后的表面具有更好的细胞黏附和增殖轮廓。由于具有良好的亲水性，经NaOH处理的基质与内皮细胞的血液相容性和细胞相容性优于经HF处理的样品。认为本研究方法可用于镁合金的表面改性，以提高镁合金的耐蚀性和生物相容性。
Owing to excellent mechanical property and biodegradation, magnesium-based alloys have been widely investigated for temporary implants such as cardiovascular stent and bone graft; however, the fast biodegradation in physiological environment and the limited surface biocompatibility hinder their clinical applications. In the present study, magnesium alloy was treated by sodium hydroxide (NaOH) and hydrogen fluoride (HF) solutions, respectively, to produce the chemical conversion layers with the aim of improving the corrosion resistance and biocompatibility. The results of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS) indicated that the chemical conversion layers of magnesium hydroxide or magnesium fluoride were obtained successfully. Sodium hydroxide treatment can significantly enhance the surface hydrophilicity while hydrogen fluoride treatment improved the surface hydrophobicity. Both the chemical conversion layers can obviously improve the corrosion resistance of the pristine magnesium alloy. Due to the hydrophobicity of magnesium fluoride, HF-treated magnesium alloy showed the relative better corrosion resistance than that of NaOH-treated substrate. According to the results of hemolysis assay and platelet adhesion, the chemical surface modified samples exhibited improved blood compatibility as compared to the pristine magnesium alloy. Furthermore, the chemical surface modified samples improved cytocompatibility to endothelial cells, the cells had better cell adhesion and proliferative profiles on the modified surfaces. Due to the excellent hydrophilicity, the NaOH-treated substrate displayed better blood compatibility and cytocompatibility to endothelial cells than that of HF-treated sample. It was considered that the method of the present study can be used for the surface modification of the magnesium alloy to enhance the corrosion resistance and biocompatibility.