COXSACKIEVIRUS-B3 MYOCARDITIS IN C3H-HEJ MICE - DESCRIPTION OF AN INBRED MODEL AND THE EFFECT OF EXERCISE ON VIRULENCE
COXSACKIEVIRUS-B3 MYOCARDITIS IN C3H-HEJ MICE - DESCRIPTION OF AN INBRED MODEL AND THE EFFECT OF EXERCISE ON VIRULENCE
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DOI：
10.1007/bf00144836
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发表时间：
1989-09-01
影响因子：
13.6
通讯作者：
REYES, MP
中科院分区：
文献类型：
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作者：
KIEL, RJ;SMITH, FE;REYES, MP
本文研究了强迫运动对近交系C_3H/HeJ小鼠柯萨奇B_3病毒性心肌炎发病的影响。形成四组小鼠（每组30只）：感染-运动（组I）;感染-未运动（组II）;未感染-运动（组III）;和未感染-未运动（组IV）。将感染的小鼠腹膜内接种1.0 ×102.1 TCID 50柯萨奇病毒B3。在第1-9天，每天对运动的动物游泳60分钟。心肌病毒滴度在感染第3天急剧升高，并在第6天和第9天通过运动显着增加。运动使总体死亡率从0-10%增加到20-40%;在第6、9和13天显著增加心脏：体重比;并增加心肌纤维坏死的程度。我们在近交系C3 H模型中再现了运动对CB 3心肌炎的加速作用。
The effect of forced exercise on the development of coxsackievirus B3 myocarditis in inbred C3H/HeJ mice was studied. Four groups of mice (30 per group) were formed: infected-exercised (Group I); infected-unexercised (Group II); uninfected-exercised (Group III); and uninfected-unexercised (Group IV). Infected mice were inoculated intraperitoneally with 1.0 .times. 102.1 TCID50 coxsackievirus B3. Exercised animals were swum daily for 60 minutes on days 1-9. Myocardial viral titers were acutely elevated on day 3 of infection and were augmented significantly by exercise on days 6 and 9. Exercise increased the overall mortality from 0-10% to 20-40%; significantly increased heart: body weight ratios on days 6, 9 and 13; and increased the extent of myocardial fiber necrosis. We have reproduced the acceleration of CB3 myocarditis by exercise in the inbred C3H model.