Nonreplication in genetic association studies of obesity and diabetes research
Nonreplication in genetic association studies of obesity and diabetes research
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DOI：
10.1093/jn/133.11.3323
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发表时间：
2003-11-01
影响因子：
4.2
通讯作者：
Allison, DB
中科院分区：
文献类型：
--
作者：
Redden, DT;Allison, DB
这篇文章的目的是提供一个关于肥胖和糖尿病相关的遗传标记物的识别现有文献的概述。具体而言，本文将审查最近的关联研究糖尿病和肥胖的需要复制的研究结果的重点。不幸的是，大量已发表的遗传标记与表型（包括糖尿病和肥胖）之间的关联尚未得到复制。总结了相关性研究未重复的潜在原因（人群分层、发表偏倚、效应异质性、I类错误和缺乏统计学把握度）的文献。提出了改进未来关联研究的建议。
The objective of this article is to provide an overview of the existing literature concerning the identification of genetic markers associated with obesity and diabetes. Specifically, this article will review recent association studies of diabetes and obesity with an emphasis on the need for the replication of findings. Unfortunately, a substantial number of the published associations between genetic markers and phenotypes, including diabetes and obesity, have not been replicated. Literature that addresses the potential reasons for the nonreplication of association studies (population stratification, publication bias, effect heterogeneity, Type I errors and lack of statistical power) is summarized. Recommendations to improve future association studies are presented.