The Binge Eating Genetics Initiative (BEGIN): study protocol
The Binge Eating Genetics Initiative (BEGIN): study protocol
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DOI：
10.1186/s12888-020-02698-7
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发表时间：
2020-06-16
期刊：
影响因子：
4.4
通讯作者：
Deboeck, Pascal R.
中科院分区：
文献类型：
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作者：
Bulik, Cynthia M.;Butner, Jonathan E.;Deboeck, Pascal R.
暴饮暴食遗传学倡议（BEGIN）是一项多管齐下的研究，旨在研究基因组、肠道微生物群和行为因素在神经性贪食症和暴饮暴食症中的相互作用。方法招募1000名符合当前神经性贪食症或暴饮暴食症诊断标准的个体，收集唾液样本进行基因分型，粪便样本进行微生物群表征，并使用适用于Apple Watch的apprerecovery record记录30天的被动数据和与饮食失调相关的行为表型。BEGIN研究基因组、肠道微生物群和行为因素的相互作用，以探索病因，并开发神经性贪食症和暴食症的风险、病程和治疗反应的预测因素。我们将优化深度被动和主动表型数据的丰富性和纵向结构，为个性化精准医疗方法奠定基础，实现及时干预，使个体能够在饮食失调行为发生之前实时破坏它们。
Background The Binge Eating Genetics Initiative (BEGIN) is a multipronged investigation examining the interplay of genomic, gut microbiota, and behavioral factors in bulimia nervosa and binge-eating disorder. Methods 1000 individuals who meet current diagnostic criteria for bulimia nervosa or binge-eating disorder are being recruited to collect saliva samples for genotyping, fecal sampling for microbiota characterization, and recording of 30 days of passive data and behavioral phenotyping related to eating disorders using the appRecovery Recordadapted for the Apple Watch. Discussion BEGIN examines the interplay of genomic, gut microbiota, and behavioral factors to explore etiology and develop predictors of risk, course of illness, and response to treatment in bulimia nervosa and binge-eating disorder. We will optimize the richness and longitudinal structure of deep passive and active phenotypic data to lay the foundation for a personalized precision medicine approach enabling just-in-time interventions that will allow individuals to disrupt eating disorder behaviors in real time before they occur.