Checkpoint and physiological apoptosis in germ cells proceeds normally in spaceflown Caenorhabditis elegans
Checkpoint and physiological apoptosis in germ cells proceeds normally in spaceflown Caenorhabditis elegans
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DOI：
10.1007/s10495-005-1323-3
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发表时间：
2005-10-01
期刊：
影响因子：
7.2
通讯作者：
Ishioka, N
中科院分区：
文献类型：
--
作者：
Higashitani, A;Higashibata, A;Ishioka, N
研究空间飞行中的环境因素对一些生理现象的影响，对人类的空间生活十分重要。细胞凋亡在后生动物的发育和组织稳态中起重要作用。在这项研究中，我们分析了线虫C.雅利安人，太空战斗之后。比较在地面或航天条件下生长的野生型或ced-1突变体中细胞尸体的数量，表明在航天条件下生殖细胞中的粗面素检查点凋亡和生理性凋亡都正常发生。此外，检查点和凋亡相关基因的表达水平在空间飞行和地面条件下具有可比性。这是第一份记录太空环境中检查点凋亡发生的报告，并表明包括人类在内的后生动物能够消除那些未能修复太空飞行期间宇宙辐射引起的DNA损伤的细胞。
It is important for human life in space to study the effects of environmental factors during spaceflight on a number of physiological phenomena. Apoptosis plays important roles in development and tissue homeostasis in metazoans. In this study, we have analyzed apoptotic activity in germ cells of the nematode C. elegans, following spacefight. Comparison of the number of cell corpses in wild type or ced-1 mutants, grown under either ground or spaceflight conditions, showed that both pachytene-checkpoint apoptosis and physiological apoptosis in germ cells occurred normally under spaceflight conditions. In addition, the expression levels of the checkpoint and apoptosis related genes are comparable between spaceflight and ground conditions. This is the first report documenting the occurrence of checkpoint apoptosis in the space environment and suggests that metazoans, including humans, would be able to eliminate cells that have failed to repair DNA lesions introduced by cosmic radiation during spaceflight.