Factor VII gene polymorphism, factor VII levels, and prevalent cardiovascular disease - The Framingham Heart Study
Factor VII gene polymorphism, factor VII levels, and prevalent cardiovascular disease - The Framingham Heart Study
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DOI：
10.1161/01.atv.20.2.593
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发表时间：
2000-02-01
影响因子：
8.7
通讯作者：
Lindpaintner, K
中科院分区：
文献类型：
--
作者：
Feng, DL;Tofler, GH;Lindpaintner, K
一些研究表明，凝血因子 VII 水平升高与心血管风险增加相关。 VII 因子基因的精氨酸/谷氨酰胺 (Arg/Gln) 多态性先前已被证明可以改变 VII 因子水平。然而，因子 VII 水平上是否存在基因/环境相互作用或与心血管疾病 (CVD) 的联系仍不确定。我们研究了弗雷明汉心脏研究的受试者，以确定 (1) 这种遗传多态性影响因子 VII 水平的程度； (2)该多态性与环境因素在因子VII水平上是否存在交互作用； (3) 多态性与 CVD、基因型数据和因子 VII 抗原水平之间的关联可在 1816 名受试者中获得。因子 VII 水平在基因型之间以累加方式存在显着差异：Gin 纯合子，82.7+/-2.5%；杂合子，92.2+/-0.7%；和 Arg 纯合子，100.5+/-0.4% (P
Elevated factor VII levels have been associated with increased cardiovascular risk in some studies. The arginine/glutamine (Arg/Gln) polymorphism of the factor VII gene has been previously shown to modify factor VII levels. However, the presence of a gene/environment interaction on factor VII levels or a link with cardiovascular disease (CVD) remains uncertain, We studied subjects from the Framingham Heart Study to determine (1) the extent to which this genetic polymorphism affects factor VII levels; (2) whether interactions exist between this polymorphism and environmental factors on factor VII levels; and (3) the association between the polymorphism and CVD, Genotype data and factor VII antigen levels were available in 1816 subjects. Factor VII levels differed significantly among genotypes in an additive fashion: Gin homozygous, 82.7+/-2.5%; heterozygous, 92.2+/-0.7%; and Arg homozygous, 100.5+/-0.4% (P