Helicobacter pylori infection is associated with a decreased risk of tooth loss in healthy Japanese men.
Helicobacter pylori infection is associated with a decreased risk of tooth loss in healthy Japanese men.
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DOI：
10.7883/yoken.66.489
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发表时间：
2013
影响因子：
2.2
通讯作者：
T. Shimoyama;Hiroyuki Higuchi;M. Matsuzaka;Daisuke Chinda;S. Nakaji;S. Fukuda
中科院分区：
文献类型：
--
作者：
T. Shimoyama;Hiroyuki Higuchi;M. Matsuzaka;Daisuke Chinda;S. Nakaji;S. Fukuda
西方国家对幽门螺杆菌感染与牙齿脱落之间的关系进行了研究；然而，这种关系仍然存在争议。尽管与西方人群不同，日本幽门螺杆菌感染的患病率较高，通常在幽门螺杆菌感染的患者中观察到萎缩性胃炎，但没有研究调查幽门螺杆菌感染与牙齿脱落之间的关系。我们调查了959名参加了大规模调查的健康成年人。统计残牙数，测定幽门螺杆菌粪便抗原和血清抗- h。螺杆菌抗体。测定血清胃蛋白酶原水平以确定萎缩性胃炎的存在。在调整年龄、体重指数（BMI）、吸烟和饮酒习惯、教育背景等因素后，进行多元logistic回归分析。在男性中，即使在调整了其他因素后，幽门螺杆菌感染也是导致所有牙齿脱落的显著降低的危险因素（OR, 0.32; 95% CI, 0.12-0.81; P < 0.05）。然而，在女性中没有发现这种关联（0.91;0.49-1.69）。计算出的萎缩性胃炎在牙齿脱落个体中存在的OR在男性和女性中都不显著。在健康的日本男性中，幽门螺杆菌感染与牙齿脱落风险降低有关。
The association between Helicobacter pylori infection and tooth loss has been studied in Western countries; however, this relationship remains controversial. Although the prevalence of H. pylori infection is higher and atrophic gastritis is usually observed in patients with H. pylori infection in Japan unlike that in Western population, no study has examined the association between H. pylori infection and tooth loss. We examined 959 healthy adults who participated in a mass survey. We counted the number of residual teeth and measured both H. pylori stool antigen and serum anti-H. pylori antibodies. Serum pepsinogen levels were measured to determine the presence of atrophic gastritis. Multiple logistic regression analysis was performed after adjustments for age, body mass index (BMI), smoking and alcohol habits, and educational background. In men, H. pylori infection was a significantly reduced risk factor for loss of all the teeth even after adjustments for other factors (OR, 0.32; 95% CI, 0.12-0.81; P < 0.05). However, such an association was not found in women (0.91; 0.49-1.69). The calculated OR for the presence of atrophic gastritis among individuals with tooth loss was not significant in both men and women. H. pylori infection was associated with a decreased risk of tooth loss in healthy Japanese men.