Vascular involvement in cognitive decline and dementia - Epidemiologic evidence from the Rotterdam Study and the Rotterdam Scan Study
Vascular involvement in cognitive decline and dementia - Epidemiologic evidence from the Rotterdam Study and the Rotterdam Scan Study
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DOI：
10.1111/j.1749-6632.2000.tb06399.x
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发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Breteler, MMB
中科院分区：
文献类型：
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作者：
Breteler, MMB
在过去的十年里，越来越多的证据表明，血管机制或血管病理参与了认知障碍和阿尔茨海默病的病因，特别是在老年人中。流行病学研究在很大程度上促成了这些概念。本文总结了两项基于人群的前瞻性研究的证据。在鹿特丹的研究中，我们调查了血管危险因素和血管疾病标记物在认知能力下降和痴呆(亚型)发展中的假定作用，并对脑白质损害的决定因素和临床意义进行了初步研究。基于这些结果，我们启动了鹿特丹扫描，在扫描中，我们前瞻性地调查了变性和血管脑变化的原因和后果。对潜在潜在机制和来自其他研究的相关发现的讨论超出了本文的范围，但已成为最近发表的几篇评论的主题。1、2
Over the last decade evidence has been accumulating for an involvement of vascular mechanisms or vascular pathology in the etiology of cognitive impairment and Alzheimer’s disease, in particular in elderly subjects. Epidemiological studies have largely contributed to these notions. In this paper the evidence from two such prospective population-based studies is summarized. In the Rotterdam Study we investigated the putative role of vascular risk factors and markers of vascular disease in the development of cognitive decline and (subtypes of) dementia, and performed an initial study on the determinants and clinical significance of cerebral white matter lesions. Based on these results, we then initiated the Rotterdam Scan, in which causes and consequences of degenerative and vascular brain changes are investigated prospectively. A discussion of potential underlying mechanisms and of related findings from other studies falls outside the scope of this paper, but has been the subject of several recently published reviews. 1, 2