Analysis of the Gut Microflora in Patients With Parkinson's Disease
Analysis of the Gut Microflora in Patients With Parkinson's Disease
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DOI：
10.3389/fnins.2019.01184
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发表时间：
2019-11-22
影响因子：
4.3
通讯作者：
Alkasir, Rashad
中科院分区：
文献类型：
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作者：
Jin, Miao;Li, Jing;Alkasir, Rashad
本研究旨在探讨中国帕金森病（PD）患者粪便菌群的组成，以及PD临床特征与抗帕金森病药物对肠道菌群的影响之间的联系。研究了72例PD病例[59例PD>1年（OPD）患者和13例新发PD（NPD）患者]。使用靶向16S rRNA基因的高通量Illumina MiSeq测序检查患者和相应健康对照（HC）粪便中的微生物群落。与相应的HC相比，OPD患者的肠道菌群含有高水平的Rikenellaceae。此外，与相应的HC相比，在NPD组中发现了显著更高水平的Turicidiaceae。Turicibacter和Prevotella属与PD严重程度评分显著相关。我们的研究结果表明，某些粪便微生物菌群与PD的临床特征密切相关，这可能会提高我们对PD的发病机制和治疗的认识。
This study was conducted to explore the composition of the fecal microflora of Chinese Parkinson's disease (PD) patients, as well as to explore links between PD clinical features and antiparkinsonian medications on the gut microflora. Seventy-two PD cases [59 patients suffering from PD for >1 year (OPD) and 13 new PD (NPD) patients] were studied. Microflora communities in the feces of the patients and corresponding healthy controls (HCs) were examined using high-throughput Illumina MiSeq sequencing targeting the 16S rRNA gene. The gut microflora of OPD patients contained high levels of Rikenellaceae compared to corresponding HCs. In addition, significantly higher levels of Turicibacteraceae were found in the NPD group compared to the corresponding HCs. The genera Turicibacter and Prevotella were significantly correlated with the PD severity scores. Our findings that some fecal microflora were closely related to PD clinical characteristics may enhance our understanding of the pathogenesis and treatment of PD.