p27 expression correlates with short-term, but not with long-term prognosis in breast cancer
p27 expression correlates with short-term, but not with long-term prognosis in breast cancer
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DOI：
10.1023/a:1010623326118
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发表时间：
2001-05-01
影响因子：
3.8
通讯作者：
Haglund, C
中科院分区：
文献类型：
--
作者：
Leivonen, M;Nordling, S;Haglund, C
需要新的预后和预测因素来调整更适合个体患者的术后治疗。p27是一种细胞周期调节因子，该蛋白质的低组织表达已显示与结直肠癌、肺癌、胃癌、前列腺癌和乳腺癌的不良预后相关。本研究对197例乳腺癌患者进行了中位随访17年，评估了免疫组化p27表达的预后价值。5年随访后，肿瘤细胞中p27表达低于50%的患者的生存率显著低于表达高于此水平的患者（p = 0.01）。然而，在更长时间的随访后，差异降低，在7年（p = 0.1）或整个随访期检查时（p = 0.67）不再显著。相关性检验显示，p27低表达与高组织学分级、高S期比例（SPF）、晚期TNM分期和阴性激素受体状态相关。结论：p27的组织表达是5年的一个重要预测因子，但不是10年或15年乳腺癌特异性生存的预测因子。
New prognostic and predictive factors are needed to adjust more appropriate therapy for individual patients after operation. p27 is a cell cycle regulator, and a low tissue expression of this protein has been shown to correlate with poor prognosis in colorectal, lung, gastric, prostate, and breast cancer. In this study on 197 breast cancer patients with a median follow-up of 17 years, the prognostic value of immunohistochemical p27 expression was evaluated. After 5 years of follow-up patients with a p27 expression in less than 50% of the tumor cells had a significantly lower survival rate than those with an expression above this level (p = 0.01). However, after longer follow-up the difference decreased and was no longer significant at 7 years (p = 0.1) or when the entire follow-up period was examined (p = 0.67). Tests for associations showed that a low p27 expression correlated with a high histologic grade, a high S-phase fraction (SPF), an advanced TNM stage and negative hormone receptor status. In conclusion: Tissue expression of p27 is a significant predictor of 5-year, but not of 10- or 15-year breast cancer specific survival.