Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations
Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations
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DOI：
10.1007/s00439-006-0189-y
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发表时间：
2006-09-01
期刊：
影响因子：
5.3
通讯作者：
Mori, Norio
中科院分区：
文献类型：
--
作者：
Nakamura, Kazuhiko;Chen, Chih-Ken;Mori, Norio
SOD2（超氧化物歧化酶2）通过催化自由基的解毒作用，在保护细胞免受自由基损伤方面起着至关重要的作用。另一方面，甲基苯丙胺给药后自由基产生引起的细胞损伤被认为是甲基苯丙胺精神病的可能病理生理机制之一。因此，我们在日本和台湾的两个独立人群中调查了SOD2多态性与甲基苯丙胺精神病发展的关系。我们在日本招募了116名甲基苯丙胺精神病患者和189名对照组，在台湾招募了135名甲基苯丙胺精神病患者和204名对照组。甲基苯丙胺组根据精神病表现的过程，分为短暂性精神病（即预后较好）和延长性精神病（即预后较差）两个临床亚型。参考2外显子Ala/Val功能多态性的基因型频率和等位基因频率，我们发现长期甲基苯丙胺精神病个体与日本和台湾对照样本在基因型频率（P值分别为0.014和0.016）和等位基因频率（P值分别为0.004和0.047）上存在显著差异。我们的研究结果表明，SOD2基因的Ala/Val多态性可能与发生甲基苯丙胺精神病的风险有关。
SOD2 (superoxide dismutase 2) plays a crucial role in protecting the cells against damage caused by free radicals, by catalyzing their detoxification. On the other hand, cell damage caused by free radical generation following methamphetamine administration has been postulated as one of the possible pathophysiological mechanisms for methamphetamine psychosis. Hence, we investigated the association of SOD2 polymorphisms with the development of methamphetamine psychosis, in two independent populations of Japan and Taiwan. We recruited 116 patients with methamphetamine psychosis and 189 controls in Japan, and 135 patients with methamphetamine psychosis and 204 controls in Taiwan. The methamphetamine group was divided into two clinical subtypes: a transient type of psychosis (i.e., good prognosis) and a prolonged type of psychosis (i.e., poor prognosis), according to the course of the manifestation of psychosis. With reference to the genotypic and allelic frequencies of Ala/Val functional polymorphism in exon 2, we found significant differences between individuals with prolonged methamphetamine psychosis and control samples from Japan and Taiwan in the genotypic (P value 0.014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis.