Morphogen signaling at the vertebrate growth cone: A few cases or a general strategy?
Morphogen signaling at the vertebrate growth cone: A few cases or a general strategy?
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DOI：
10.1002/neu.20161
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发表时间：
2005-09-15
期刊：
影响因子：
--
通讯作者：
Bovolenta, P
中科院分区：
文献类型：
--
作者：
Bovolenta, P
轴突导航依赖于生长锥体感知和解释沿其轨迹呈现的吸引和排斥的引导线索的能力。对于大多数神经元来说，这一过程是由少数保守的配体-受体信号系统家族介导的，包括EPhin/Eph、netrins/DCC-uc5、Slits/Robo和Signaphorins/Plexin-Neuropilin。最近的研究表明，一些神经元也对众所周知的分泌型信号分子做出反应，这些分子最著名的作用是作为形态发生者，如BMP7、SHH、FGF8和Wnt。因此，视网膜神经节细胞轴突的导航受到成纤维细胞生长因子、SHH和可能的BMP信号的影响。类似地，脊髓中的连合神经元对BMP、SHH和WNT的活动依次做出反应，向和远离它们的中间靶点--底板延伸。将总结支持这一结论的数据，并讨论形态成因如何在生长锥体上发出信号。(C)2005年威利期刊公司。
Axon navigation relies on the competence of growth cones to sense and interpret attractive and repulsive guidance cues present along their trajectory. For most neurons, this process is mediated by a limited number of conserved families of ligand-receptor signaling systems, including Ephrin/Eph, Netrins/DCC-Unc5, Slits/Robo, and Semaphorins/Plexin-Neuropilin. Recent studies have demonstrated that some neurons respond also to well-known secreted signaling molecules, best known for their roles as morphogens, such as BMP7, SHH, FGF8, and Wnt. Thus, retina ganglion cell axon navigation is influenced by FGF, SHH, and possibly BMP signaling. Similarly, commissural neurons in the spinal cord respond sequentially to the activity of BMP, SHH, and Wnt to extend toward and away from their intermediate target, the floor plate. The data that support this conclusion will be summarized and how morphogens may signal at the growth cone will be discussed. (c) 2005 Wiley Periodicals, Inc.