A randomized, controlled pilot study of acupuncture treatment for menopausal hot flashes
A randomized, controlled pilot study of acupuncture treatment for menopausal hot flashes
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DOI：
10.1097/gme.0b013e31816d5b03
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发表时间：
2008-11-01
影响因子：
2.7
通讯作者：
Valaskatgis, Peter
中科院分区：
文献类型：
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作者：
Avis, Nancy E.;Legault, Claudine;Valaskatgis, Peter
目的：探讨针刺减少围绝经期和绝经后妇女潮热的可行性。设计：从两个临床中心收集56例年龄44~55岁，无月经，每天至少潮热4次的妇女，随机分为3组：常规护理组(n=19)、假针刺组(n=18)和中药针刺组(n=19)。针灸治疗每周两次，连续8周。假针刺组在非治疗部位进行浅针治疗。中医针刺组接受了基于中医诊断的四种治疗方法之一。在研究期间，常规护理参与者被指示不要开始任何新的潮热治疗。每天的日记被用来跟踪潮热的频率和严重程度。每天的平均指数评分是基于轻度、中度和重度潮热的次数。根据临床中心的基线值对随访分析进行调整。结果：尽管三个研究组之间的差异不显著，但在第1周和第8周期间，所有组的潮热平均频率都显著降低(P=0.01)。然而，两个针刺组的下降幅度明显大于常规护理组(P<；0.05)，但彼此之间没有差异。潮热指数得分的结果遵循了类似的模式。在潮热干扰、睡眠、情绪、与健康相关的生活质量或心理健康方面的变化没有显著影响。结论：这些结果表明要么有很强的安慰剂效应，要么传统针灸和假针灸都显著减少了潮热频率。
Objective: To investigate the feasibility of conducting a randomized trial of the effect of acupuncture in decreasing hot flashes in peri- and postmenopausal women.Design: Fifty-six women ages 44 to 55 with no menses in the past 3 months and at least four hot flashes per day were recruited from two clinical centers and randomized to one of three treatment groups: usual care (n = 19), sham acupuncture (n = 18), or Traditional Chinese Medicine acupuncture (n = 19). Acupuncture treatments were scheduled twice weekly for 8 consecutive weeks. The sham acupuncture group received shallow needling in nontherapeutic sites. The Traditional Chinese Medicine acupuncture group received one of four treatments based oil a Traditional Chinese Medicine diagnosis. Usual care participants were instructed to not initiate any new treatments for hot flashes during the study. Daily diaries were used to track frequency and severity of hot flashes. The mean daily index score was based oil the number of mild, moderate, and severe hot flashes. Follow-up analyses were adjusted for baseline values, clinical center. age, and body mass index.Results: There was a significant decrease in mean frequency of hot flashes between weeks 1 and 8 across all groups (P =0.01), although the differences between the three Study groups were not significant. However, the two acupuncture groups showed a significantly greater decrease than the usual care group (P < 0.05), but did not differ from each other. Results followed a similar pattern for the hot flash index score. There were no significant effects for changes in hot flash interference, sleep, mood, health-related quality of life, or psychological well-beingConclusions: These results suggest either that there is a strong placebo effect or that both traditional and sham acupuncture significantly reduce hot flash frequency.