Effect of rotavirus vaccine on childhood diarrhea mortality in five Latin American countries
Effect of rotavirus vaccine on childhood diarrhea mortality in five Latin American countries
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DOI：
10.1016/j.vaccine.2015.06.058
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发表时间：
2015-07-31
期刊：
影响因子：
5.5
通讯作者：
De la Hoz-Restrepo, Fernando
中科院分区：
文献类型：
--
作者：
Paternina-Caicedo, Angel;Parashar, Umesh D.;De la Hoz-Restrepo, Fernando
背景：本研究的目的是估计2006年引入轮状病毒疫苗（RV）的五个拉丁美洲国家儿童中引入轮状病毒疫苗（RV）与降低全因腹泻死亡率之间的关系。方法：从泛美卫生组织死亡率数据库中收集2002年至2009年期间的腹泻死亡率数据，涉及2006年引入RV的5个“疫苗采纳国”（巴西、萨尔瓦多、墨西哥、尼加拉瓜和巴拿马）和2009年未引入RV的4个“对照国”（阿根廷、智利、哥斯达黎加和巴拉圭）。进行时间趋势分析，估计效果和95%置信区间（Cl）。结果：除巴拿马外，五个采用疫苗的国家在2006年至2009年接种疫苗后死亡率均有显著下降趋势，而对照国家在这几年中没有出现下降。此外，两名儿童全因腹泻死亡率的下降趋势
Background: The aim of this study was to estimate the association between rotavirus vaccine (RV) introduction and reduction of all-cause diarrhea death rates among children in five Latin American countries that introduced RV in 2006.Methods: Diarrhea mortality data was gathered from 2002 until 2009 from the Pan American Health Organization Mortality Database for five "vaccine adopter" countries (Brazil, El Salvador, Mexico, Nicaragua, and Panama) that introduced RV in 2006 and four "control" countries (Argentina, Chile, Costa Rica, and Paraguay) that did not introduce RV by 2009. Time trend analyses were carried out, and effects and 95% confidence intervals (Cl) were estimated.Results: Each of the five vaccine adopter countries, except Panama, showed a significant trend in declining mortality rates during the post-vaccine period from 2006 to 2009, whereas no decline was seen in control countries during these years. Furthermore, trends of reduction of all-cause diarrhea mortality in both children