Participation by purines in the modulation of norepinephrine release by methoxamine.
Participation by purines in the modulation of norepinephrine release by methoxamine.
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嘌呤参与甲氧胺释放去甲肾上腺素的调节。
DOI：
10.1016/0014-2999(91)90236-j
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发表时间：
1991
影响因子：
5
通讯作者：
Westfall,DP
中科院分区：
文献类型：
--
作者：
Shinozuka,K;Sedaa,KO;Bjur,RA;Westfall,DP
α1受体激动剂甲氧胺可通过哌唑嗪敏感机制减少神经刺激引起的大鼠尾动脉去甲肾上腺素的释放。甲氧胺的作用也可被嘌呤受体拮抗剂8-(对磺苯基)茶碱所拮抗，提示内源性嘌呤参与了这一过程。事实上，甲氧胺导致腺嘌呤核苷酸和腺苷的释放，这一作用被哌唑嗪阻断。这些结果表明，甲氧胺释放三磷酸腺苷或相关的嘌呤，从而通过作用于连接前的嘌呤受体而减少递质释放。
Theα1-receptor agonist methoxamine reduced, by a prazosin sensitive mechanism, the nerve stimulation evoked release of norepinephrine in the rat caudal artery. The effect of methoxamine was also antagonized by the purinoceptor antagonist 8-(p-sulfophenyl)theophylline suggesting an involvement of endogenous purines in this process. Indeed, methoxamine caused the release of adenine nucleotides and adenosine, an action which was blocked by prazosin. These results suggest that methoxamine releases ATP or a related purine which in turn decreases transmitter release by acting on prejunctional purinoceptors.