Negative Effects of Long-duration Spaceflight on Paraspinal Muscle Morphology
Negative Effects of Long-duration Spaceflight on Paraspinal Muscle Morphology
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DOI：
10.1097/brs.0000000000002959
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发表时间：
2019-06-15
期刊：
影响因子：
3
通讯作者：
Bouxsein, Mary L.
中科院分区：
文献类型：
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作者：
Burkhart, Katelyn;Allaire, Brett;Bouxsein, Mary L.
研究设计。预期病例系列：客观。确定长时间太空飞行和在地球上恢复后脊柱旁肌肉横截面积(CSA)和衰减的变化。确定飞行中锻炼和肌肉萎缩之间的联系。背景数据摘要。长时间的太空飞行会导致明显的肌肉萎缩。然而，停用的另一个负面后果是肌肉中的脂肪渗透。值得注意的是，很少有研究调查航天对肌肉内脂肪渗透的影响，或者肌肉萎缩与飞行锻炼的关系。我们分析了17名长期飞行的宇航员和宇航员的腰椎(L1/L2)的计算机断层扫描，以确定脊柱旁肌肉的CSA和衰减。计算机断层扫描在飞行前、飞行后、飞行后一年收集，并在飞行后2至4年收集子集。我们测量了竖脊肌(ES)、多裂肌(MF)、腰大肌(PS)和腰方肌(QL)的CSA(Mm2)和衰减(Hounsfield Units)。我们使用配对t检验来比较飞行后每个时间点的肌肉形态与飞行前的值以及皮尔逊相关系数，以确定肌肉变化与飞行训练之间的关联。与飞行前相比，飞行后Es、Mf和QL CSA和衰减显著降低(分别为-4.6%至-8.4%和-5.9%至-8.8%，p
Study Design. Prospective case series.Objective. Determine the extent of paraspinal muscle cross-sectional area (CSA) and attenuation change after long-duration spaceflight and recovery on Earth. Determine association between in-flight exercise and muscle atrophy.Summary of Background Data. Long-duration spaceflight leads to marked muscle atrophy. However, another negative consequence of disuse is intramuscular fatty infiltration. Notably, few studies have investigated the effects of spaceflight on intramuscular fatty infiltration, or how muscle atrophy is associated with in-flight exercise.Methods. We analyzed computed tomography scans of the lumbar spine (L1/L2) from 17 long-duration astronauts and cosmonauts to determine paraspinal muscle CSA and attenuation. Computed tomography scans were collected preflight, postflight, 1-year postflight, and, in a subset, 2 to 4 years postflight. We measured CSA (mm 2) and attenuation (Hounsfield Units) of the erector spinae (ES), multifidus (MF), psoas (PS), and quadratus lumborum (QL) muscles. We used paired t tests to compare muscle morphology at each postflight time point to preflight values and Pearson correlation coefficients to determine the association between muscle changes and in-flight exercise.Results. ES, MF, and QL CSA and attenuation were significantly decreased postflight compared with preflight (-4.6% to -8.4% and -5.9% to -8.8%, respectively, p