Aerosol Delivery of Curcumin Reduced Amyloid-β Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer's Disease.
Aerosol Delivery of Curcumin Reduced Amyloid-β Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer's Disease.
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DOI：
10.3233/jad-160289
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Pham W
中科院分区：
文献类型：
--
作者：
McClure R;Ong H;Janve V;Barton S;Zhu M;Li B;Dawes M;Jerome WG;Anderson A;Massion P;Gore JC;Pham W
我们报告了一种新的方法，用于通过吸入气雾剂将姜黄素递送到大脑，用于潜在的阿尔茨海默病治疗。与年龄匹配的未治疗的小鼠相比，当年轻的5XFAD小鼠用可吸入姜黄素治疗较长时间时，下托和海马中的斑块部分的百分比显著降低。此外，治疗的动物表现出显著改善的整体认知功能，在本工作过程中没有观察到与可吸入姜黄素相关的登记的全身或肺毒性。
We report a novel approach for the delivery of curcumin to the brain via inhalation of the aerosol for the potential treatment of Alzheimer’s disease. The percentage of plaque fraction in the subiculum and hippocampus reduced significantly when young 5XFAD mice were treated with inhalable curcumin over an extended period of time compared to age-matched nontreated counterparts. Further, treated animals demonstrated remarkably improved overall cognitive function, no registered systemic or pulmonary toxicity associated with inhalable curcumin observed during the course of this work.