Fluorine in medicinal chemistry and chemical biology
Fluorine in medicinal chemistry and chemical biology
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DOI：
10.1002/9781444312096
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发表时间：
2009-04
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影响因子：
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通讯作者：
I. Ojima
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文献类型：
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作者：
I. Ojima
引言第1章“氟的独特性质及其与药物化学和化学生物学的相关性”，作者：Takashi Yamazaki、Takeo Taguchi和Iwao Ojima药物化学第2章“氟化前列腺素：替尼前列素的开发，一种新的抗青光眼剂”由Yasushi Matsumura第3章“用于CNS药物发现和开发的氟化构象限制谷氨酸类似物”由Atsuro Nakazato第4章“Fluorinated Inhibitors of Matrix Metalloproteinases”by Roberta Sinisi，Monika Jagodzinska，Gabriele Rupani，Florent Huguenot，Monica Sani，Alessandro Volonterio，Raffaella Maffezzoni and Matteo Zanda第5章“Fluoro-Taxoid Anticancer Agents”by Antonella Pepe，拉里萨库兹涅佐娃，Liang Sun and Iwao Ojima第6章“Antimalarial Fluoroartemisinins：增加的代谢和化学稳定性“，Jean-Pierre Begue，Daniele Bonnet-Delpon，第7章“氟化核苷的合成和生物活性”，Tokumi Maruyama，Masahiro Ikejiri，Kunisuke Izawa和Tomoyuki Onishi药物化学和化学生物学的合成方法第8章“通过gem -二氟亚甲基合成gem -二氟亚甲基化核苷”第9章“含氟氨基酸合成的最新进展”第10章“用于取代酰胺键和肽键的含氟部分”田口武雄和柳井光第11章“作为药物发现支架的全氟杂芳族体系”大卫阿姆斯特朗和马修W.作者：Emma L.放大图片作者：John A. Christopher，大卫D.作者：米勒Smith和Antonio Vong第12章“gem -Difluorocyclopropanes as key building blocks for novel biological active molecules”作者Toshiyuki Itoh第13章“Fluorous Mixture Synthesis（FMS）of Drug-Like Molecules and Enantiomers，Stereoisomers，and Analogs of Natural Products”作者Wei Zhang第14章“Fluorine-18 Radiopharmaceuticals”作者Michael R. Kilbourn和Xia Shao氟化氨基酸和肽在化学生物学和药理学中的应用第15章“应用人工模型系统研究卷曲螺旋蛋白质天然环境中氟化氨基酸的相互作用”Mario Salwiczek，Toni Vagt和Beate Koksch第16章“蛋白质设计和化学生物学中的氟化氨基酸和生物分子”He Meng，Ginevra A. Clark和Krishna Kumar第17章“氟化对甲烷生物有机性质的影响”，John F。Honek第18章“Structure analysis of membrane-active peptides using 19 F-labeled amino acids and solid state NMR”作者Parvesh Wadhwani和Erik Strandberg第19章“Metabolism of Fluorine-containing Drugs using in vivo Magnetic Resonance Spectroscopy”作者Erika Schneider附录“FDA批准的含氟活性药物成分”作者Elizabeth Pollina-Corpine，Manisha Das，and Iwao Ojima
Introduction Chapter 1 "Unique Properties of Fluorine and Their Relevance to Medicinal Chemistry and Chemical Biology" by Takashi Yamazaki, Takeo Taguchi and Iwao Ojima Medicinal Chemistry Chapter 2 "Fluorinated Prostanoids: Development of Tafluprost, a New Anti-glaucoma Agent" by Yasushi Matsumura Chapter 3 "Fluorinated conformationally restricted glutamate analogs for CNS drug discovery and development" by Atsuro Nakazato Chapter 4 "Fluorinated Inhibitors of Matrix Metalloproteinases" by Roberta Sinisi, Monika Jagodzinska, Gabriele Candiani, Florent Huguenot, Monica Sani, Alessandro Volonterio, Raffaella Maffezzoni and Matteo Zanda Chapter 5 "Fluoro-Taxoid Anticancer Agents" by Antonella Pepe, Larisa Kuznetsova, Liang Sun and Iwao Ojima Chapter 6 "Antimalarial Fluoroartemisinins: Increased Metabolic and Chemical Stability"by Jean-Pierre Begue, Daniele Bonnet-Delpon Chapter 7 "Synthesis and Biological Activity of Fluorinated Nucleosides" by Tokumi Maruyama, Masahiro Ikejiri, Kunisuke Izawa and Tomoyuki Onishi Synthetic methods for medicinal chemistry and chemical biology Chapter 8 "Synthesis of gem -Difluoromethylenated Nucleosides via gem -Difluoromethylene-Containing Building Blocks" by Wei-Dong Meng and Feng-Ling Qing Chapter 9 "Recent Advances in the Syntheses of Fluorinated Amino Acids" by Kenji Uneyama Chapter 10 "Fluorinated Moieties for Replacement of Amide and Peptide Bonds" by Takeo Taguchi and Hikaru Yanai Chapter 11 "Perfluorinated Heteroaromatic Systems as Scaffolds for Drug Discovery" by David Armstrong, Matthew W. Cartwright, Emma L. Parks, Graham Pattison, Graham Sandford, Rachel Slater, John A. Christopher, David D. Miller, Paul W. Smith and Antonio Vong Chapter 12 " gem -Difluorocyclopropanes as key building blocks for novel biologically active molecules" by Toshiyuki Itoh Chapter 13 "Fluorous Mixture Synthesis (FMS) of Drug-Like Molecules and Enantiomers, Stereoisomers, and Analogs of Natural Products" by Wei Zhang Chapter 14 "Fluorine-18 Radiopharmaceuticals" by Michael R. Kilbourn and Xia Shao Applications of fluorinated amino acids and peptides to chemical biology and pharmacology Chapter 15 "Application of Artificial Model Systems to Study the Interactions of Fluorinated Amino Acids within the Native Environment of Coiled Coil Proteins" by Mario Salwiczek, Toni Vagt and Beate Koksch Chapter 16 "Fluorinated Amino Acids and Biomolecules in Protein Design and Chemical Biology" by He Meng, Ginevra A. Clark , and Krishna Kumar Chapter 17 "Effects of Fluorination on the Bioorganic Properties of Methionine" by John F. Honek Chapter 18 "Structure analysis of membrane-active peptides using 19 F-labeled amino acids and solid state NMR" by Parvesh Wadhwani and Erik Strandberg Chapter 19 "Metabolism of Fluorine-containing Drugs using in vivo Magnetic Resonance Spectroscopy" by Erika Schneider Appendix "FDA-Approved Active Pharmaceutical Ingredients Containing Fluorine" by Elizabeth Pollina-Cormier, Manisha Das, and Iwao Ojima