Enantioselective catalysis of ketoester-ene reaction of silyl enol ether to construct quaternary carbons by chiral dicationic Palladium(II) complexes
Enantioselective catalysis of ketoester-ene reaction of silyl enol ether to construct quaternary carbons by chiral dicationic Palladium(II) complexes
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DOI：
10.1021/ja076539f
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发表时间：
2007-10-31
影响因子：
15
通讯作者：
Aikawa, Kohsuke
中科院分区：
文献类型：
--
作者：
Mikami, Koichi;Kawakami, Yuji;Aikawa, Kohsuke
SEGPHOS-Pd络合物催化酮-酯-烯与硅烯醇醚的双阳离子反应可以高产率和对映体选择性地生成具有季碳中心的烯产品。即使催化剂的负载量更低(高达0.01mol%)，也不会显著降低产率和对映体选择性；这将为手性Lewis酸催化的工业应用打开大门。
Dicationic SEGPHOS-Pd complex-catalyzed ketoester-ene reaction with silyl enol ether can be achieved to produce an ene product with a quaternary carbon center in high yield and enantioselectivity. Even lower catalyst loading (up to 0.01 mol%) can be performed without a significant decrease in yield and enantioselectivity; this will open doors to industrial applications of chiral Lewis acid catalysis.