Impaired Aerobic Capacity and Physical Functional Performance in Older Heart Failure Patients With Preserved Ejection Fraction: Role of Lean Body Mass
Impaired Aerobic Capacity and Physical Functional Performance in Older Heart Failure Patients With Preserved Ejection Fraction: Role of Lean Body Mass
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DOI：
10.1093/gerona/glt011
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发表时间：
2013-08-01
影响因子：
5.1
通讯作者：
Kitzman, Dalane W.
中科院分区：
文献类型：
--
作者：
Haykowsky, Mark J.;Brubaker, Peter H.;Kitzman, Dalane W.
背景资料。运动耐受是心力衰竭患者的主要慢性症状，并保留射血分数(HFPEF)，这是老年人最常见的心力衰竭形式，可由心脏、血管和骨骼肌异常引起，物理条件解除可进一步恶化。然而，目前尚不清楚骨骼肌异常是否会导致HFPEF患者的运动不耐受。这项研究评估了60名老年(69+/-7岁)HFPEF患者和40名年龄匹配的健康对照组的瘦体重、最大运动耗氧量(VO2)和短运动能力电池。与健康对照组相比，HFPEF组总瘦体重峰值百分比(60.1+/-0.8%比66.6+/-1.0%，p<；0.0001)和腿部瘦体重峰值百分比(57.9+/-0.9%比63.7+/-1.1%，p=0.0001)显著降低。峰值VO2严重降低，包括以腿部瘦体重为指标时(79.3+/-18.5vs.104.3+/-20.4ml/kg/min，p
Background. Exercise intolerance is the primary chronic symptom in patients with heart failure and preserved ejection fraction (HFPEF), the most common form of heart failure in older persons, and can result from abnormalities in cardiac, vascular, and skeletal muscle, which can be further worsened by physical deconditioning. However, it is unknown whether skeletal muscle abnormalities contribute to exercise intolerance in HFPEF patients.Methods. This study evaluated lean body mass, peak exercise oxygen consumption (VO2), and the short physical performance battery in 60 older (69 +/- 7 years) HFPEF patients and 40 age-matched healthy controls.Results. In HFPEF versus healthy controls, peak percent total lean mass (60.1 +/- 0.8% vs. 66.6 +/- 1.0%, p < .0001) and leg lean mass (57.9 +/- 0.9% vs. 63.7 +/- 1.1%, p =.0001) were significantly reduced. Peak VO2 was severely reduced including when indexed to leg lean mass (79.3 +/- 18.5 vs. 104.3 +/- 20.4 ml/kg/min, p