Erythrocyte-platelet hybrid membranes coating polypyrrol nanoparticles for enhanced delivery and photothermal therapy
Erythrocyte-platelet hybrid membranes coating polypyrrol nanoparticles for enhanced delivery and photothermal therapy
复制标题
红细胞-血小板杂化膜涂覆聚吡咯纳米颗粒，用于增强递送和光热治疗
DOI：
10.1039/c8tb02143k
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发表时间：
2018-11-21
影响因子：
7
通讯作者：
Shen, Shun
中科院分区：
文献类型：
--
作者：
Liu, Yao;Wang, Xuejun;Shen, Shun
聚吡咯纳米颗粒（PPy NPs）由于在近红外（NIR）照射下能够产生热量而被广泛研究用于肿瘤的光热治疗（PTT）。开发无毒、自靶向和长循环的PPy生物材料以最大化光热效应仍然具有挑战性。在这里，我们表明，与融合的红细胞（RBC）和血小板（PLT）膜包裹的PPy NPs可以在直接近红外辐射（NIR）下杀死肿瘤细胞。所得RBC-PLT杂化膜包被的PPy NP（PPy@[R-P] NP）具有RBC和PLT的特性，表现出长循环时间和自靶向性质。经尾静脉注射PPy@[R-P] NPs后，肿瘤血管在近红外激光照射下受到光热刺激而损伤，诱导大量微血栓形成。由于PLT膜的存在，大量PPy@[R-P] NPs被成功募集到微血栓形成部位。结果，改善了纳米材料在肿瘤组织中的分布，实现了优异的光热治疗。所得PPy@[R-P] NP可有助于抗肿瘤PTT。
Polypyrrole nanoparticles (PPy NPs) have been extensively studied for photothermal therapy (PTT) of tumors because they can generate heat upon near-infrared (NIR) irradiation. Developing non-toxic, self-targeting and long-circulating PPy biomaterials to maximize photothermal effects remains challenging. Here, we show that PPy NPs camouflaged with fusing red blood cells (RBC) and platelet (PLT) membranes can kill tumor cells under direct near infrared irradiation (NIR). The resulting RBC-PLT hybrid membrane-coated PPy NPs (PPy@[R-P] NPs) possess characteristics of both RBC and PLT, exhibiting long circulation times and self-targeting properties. After administration of PPy@[R-P] NPs via tail vein, tumor vessels were injured by photothermal stimulation under NIR laser exposure, which induced a large amount of microthrombosis. Due to the existence of PLT membranes, a large number of PPy@[R-P] NPs were successfully recruited to the microthrombosis sites. As a result, the distribution of nanomaterials in the tumor tissues was improved, and excellent photothermal treatment was achieved. The resulting PPy@[R-P] NPs may contribute to anti-tumor PTT.