Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model.
Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model.
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DOI：
10.1117/1.2697735
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发表时间：
2007
影响因子：
3.5
通讯作者：
Inseok Seo;J. You;C. Hayakawa;V. Venugopalan
中科院分区：
文献类型：
--
作者：
Inseok Seo;J. You;C. Hayakawa;V. Venugopalan
微扰和微分蒙特卡罗（pMC/dMC）方法结合非线性优化算法是近年来提出的一种求解区域非均匀混浊介质中光子逆迁移问题的方法。我们证明了应用pMC/dMC方法恢复的光学特性在一个两层的扩展上皮组织模型从实验测量的空间分辨漫反射。结果表明，pMC/dMC方法提供了一种快速，准确的方法来解决两个区域的逆光子迁移问题的传输制度，即，在空间尺度小于传输平均自由程和介质中的光散射不需要占主导地位的吸收。pMC/dMC的方法被发现是有效的吸收（50至400%）和散射（70至130%）的扰动范围很广。从空间分辨漫反射测量的光学性质的恢复检查不同的源-检测器分离集。这些结果提供了一些指导紧凑的光纤为基础的探针的设计，以确定和分离的光学特性从上皮和基质层的浅表组织。
The use of perturbation and differential Monte Carlo (pMC/dMC) methods in conjunction with nonlinear optimization algorithms were proposed recently as a means to solve inverse photon migration problems in regionwise heterogeneous turbid media. We demonstrate the application of pMC/dMC methods for the recovery of optical properties in a two-layer extended epithelial tissue model from experimental measurements of spatially resolved diffuse reflectance. The results demonstrate that pMC/dMC methods provide a rapid and accurate approach to solve two-region inverse photon migration problems in the transport regime, that is, on spatial scales smaller than a transport mean free path and in media where optical scattering need not dominate absorption. The pMC/dMC approach is found to be effective over a broad range of absorption (50 to 400%) and scattering (70 to 130%) perturbations. The recovery of optical properties from spatially resolved diffuse reflectance measurements is examined for different sets of source-detector separation. These results provide some guidance for the design of compact fiber-based probes to determine and isolate optical properties from both epithelial and stromal layers of superficial tissues.