Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline.
Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline.
复制标题
7-异硫氰酸四氢异喹啉对人苯乙醇胺 N-甲基转移酶的时间依赖性灭活。
DOI：
10.1016/j.bmcl.2009.01.014
复制
发表时间：
2009
影响因子：
2.7
通讯作者：
McLeish,MichaelJ
中科院分区：
文献类型：
--
作者：
Wu,Qian;Caine,JoanneM;Thomson,StuartA;Slavica,Meri;Grunewald,GaryL;McLeish,MichaelJ
Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system. Here we describe the synthesis and characterization of 7-SCN tetrahydroisoquinoline as an affinity label for human PNMT.
