Caveolin-1, a stress-related oncotarget, in drug resistance.
Caveolin-1, a stress-related oncotarget, in drug resistance.
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Caveolin-1，一种与压力相关的肿瘤靶标，在耐药性中的作用
DOI：
10.18632/oncotarget.5789
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发表时间：
2015-11-10
期刊：
影响因子：
--
通讯作者：
Situ H
中科院分区：
文献类型：
--
作者：
Wang Z;Wang N;Liu P;Peng F;Tang H;Chen Q;Xu R;Dai Y;Lin Y;Xie X;Peng C;Situ H
窖蛋白 - 1（Cav - 1）既是一种肿瘤抑制蛋白，也是一种癌蛋白。在癌症晚期，Cav - 1过表达现象屡见不鲜，且与ABC转运蛋白、癌症干细胞群、有氧糖酵解活性及自噬呈正相关。Cav - 1与多种应激因素相关，包括放疗、流体剪切力、氧化应激以及紫外线照射等，并且与诸如AMP激活蛋白激酶等应激信号相互作用。最后，本文提出了癌症发展过程中Cav - 1的波动模型，并认为Cav - 1是一种应激信号且具有细胞保护作用。Cav - 1的缺失可能会增加对致癌事件的易感性。然而，有必要开展研究以探究Cav - 1与应激信号之间潜在的分子网络。
Caveolin-1 (Cav-1) is both a tumor suppressor and an oncoprotein. Cav-1 overexpression was frequently confirmed in advanced cancer stages and positively associated with ABC transporters, cancer stem cell populations, aerobic glycolysis activity and autophagy. Cav-1 was tied to various stresses including radiotherapy, fluid shear and oxidative stresses and ultraviolet exposure, and interacted with stress signals such as AMP-activated protein kinase. Finally, a Cav-1 fluctuation model during cancer development is provided and Cav-1 is suggested to be a stress signal and cytoprotective. Loss of Cav-1 may increase susceptibility to oncogenic events. However, research to explore the underlying molecular network between Cav-1 and stress signals is warranted.