Abnormal functional connectivity of brain network hubs associated with symptom severity in treatment-naive patients with obsessive–compulsive disorder: A resting-state functional MRI study
Abnormal functional connectivity of brain network hubs associated with symptom severity in treatment-naive patients with obsessive–compulsive disorder: A resting-state functional MRI study
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DOI：
10.1016/j.pnpbp.2015.12.003
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发表时间：
2016-04
影响因子：
5.6
通讯作者：
Lin Tian;C. Meng;Ying Jiang;Qunfeng Tang;Shuai Wang;Xiyao Xie;Xiangshuai Fu;Chunhui Jin;
中科院分区：
文献类型：
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作者：
Lin Tian;C. Meng;Ying Jiang;Qunfeng Tang;Shuai Wang;Xiyao Xie;Xiangshuai Fu;Chunhui Jin;
在强迫症（OCD）患者中观察到异常的脑网络。然而，详细的网络枢纽和连接的变化仍然不清楚，在治疗初治的强迫症患者。在这里，我们试图确定患者是否表现出枢纽相关的连接变化，在他们的全脑functional networks.MethodsWe静息态功能磁共振成像数据和基于体素的图论分析，调查功能连接强度和枢纽的全脑网络在29个治疗初治患者强迫症和29个年龄和性别匹配的健康对照。相关性分析应用于潜在的协会与强迫症symptomseverity.ResultsOCD选择性地针对大脑区域的功能连接强度高于平均水平，包括大脑网络枢纽，主要分布在皮质-纹状体-丘脑-皮质（CSTC）电路，另外顶叶，枕叶，颞叶和小脑区域。此外，受影响的功能连接强度在小脑，内侧眶额皮质和上级枕叶皮质与全球OCD症状severity.ConclusionOur研究结果提供了证据，OCD相关的脑网络枢纽的变化，不仅在CSTC电路，但更多地分布在整个大脑网络。数据表明，全脑网络枢纽分析是有用的了解强迫症的病理生理。
ObjectiveAbnormal brain networks have been observed in patients with obsessive–compulsive disorder (OCD). However, detailed network hub and connectivity changes remained unclear in treatment-naive patients with OCD. Here, we sought to determine whether patients show hub-related connectivity changes in their whole-brain functional networks.MethodsWe used resting-state functional magnetic resonance imaging data and voxel-based graph-theoretic analysis to investigate functional connectivity strength and hubs of whole-brain networks in 29 treatment-naive patients with OCD and 29 age- and gender-matched healthy controls. Correlation analysis was applied for potential associations with OCD symptom severity.ResultsOCD selectively targeted brain regions of higher functional connectivity strength than the average including brain network hubs, mainly distributed in the cortico–striato–thalamo-cortical (CSTC) circuits and additionally parietal, occipital, temporal and cerebellar regions. Moreover, affected functional connectivity strength in the cerebellum, the medial orbitofrontal cortex and superior occipital cortex was significantly associated with global OCD symptom severity.ConclusionOur results provide the evidence about OCD-related brain network hub changes, not only in the CSTC circuits but more distributed in whole brain networks. Data suggest that whole brain network hub analysis is useful for understanding the pathophysiology of OCD.