A Novel Acoustomicrofluidic Nebulization Technique Yielding New Crystallization Morphologies
A Novel Acoustomicrofluidic Nebulization Technique Yielding New Crystallization Morphologies
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DOI：
10.1002/adma.201602040
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发表时间：
2018-01-18
影响因子：
29.4
通讯作者：
Yeo, Leslie Y.
中科院分区：
文献类型：
--
作者：
Ahmed, Heba;Lee, Lillian;Yeo, Leslie Y.
一种新的声学微流体雾化平台的证明，这是由于其独特的能力，访问中间蒸发速率制度显着快于缓慢的溶剂蒸发，但大大低于实现喷雾干燥，是能够产生新的晶体形态，尚未被报告在模型无机和有机系统。此外，简要显示了在雾化过程中溶剂蒸发时，在单个同时步骤中将单晶同时包封在可生物降解聚合物涂层内以及结晶过程的可能性。该平台不仅具有通过并行采用大量这些低成本微型装置来实现工业相关颗粒生产率的高度可扩展性的潜力，而且在能量利用方面也可以优于传统的喷雾干燥，因为与高频超声波微型装置及其环境温度操作相关的巨大效率。
A novel acoustic microfluidic nebulization platform is demonstrated, which, due to its unique ability to access intermediate evaporation rate regimes-significantly faster than that in slow solvent evaporation but considerably below that achieved in spray drying, is capable of producing novel crystal morphologies that have yet to be reported in both model inorganic and organic systems. In addition, the potential for simultaneously encapsulating single crystals within a biodegradable polymeric coating in a single simultaneous step together with the crystallization process as the solvent evaporates during nebulization is briefly shown. The platform not only has the potential to be highly scalable by employing a large number of these low-cost miniature devices in parallel to achieve industrially relevant particle production rates, but could also be advantageous over conventional spray drying in terms of energy utilization, given the tremendous efficiency associated with the high-frequency ultrasonic microdevice as well as its ambient temperature operation.