Standardized assessment of whole body adipose tissue topography by MRI
Standardized assessment of whole body adipose tissue topography by MRI
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DOI：
10.1002/jmri.20292
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发表时间：
2005-04-01
影响因子：
4.4
通讯作者：
Schick, F
中科院分区：
文献类型：
--
作者：
Machann, J;Thamer, C;Schick, F
目的：为了评估标准化的全身脂肪组织地形图在一个队列中的受试者在2型糖尿病的风险增加，并比较脂肪分布在亚组人体测量（年龄，体重指数[BMI]）和代谢参数（胰岛素敏感性）。材料和方法：共80名志愿者（40名女性，40名男性）进行了T1加权MR成像的整个身体。考虑到参与者的不同身体结构，计算标准化脂肪组织（AT）曲线。将测量数据插值到定义数量的采样点，从而能够直接比较与车身结构无关的轮廓。对女性和男性的四个年龄组和三个BMI组的平均曲线和区域依赖性标准差进行了比较。结果：所有受试者均获得了可靠的脂肪组织轮廓。在BMI匹配的亚组中，女性的AT和皮下腹部AT显著高于男性（P < 0.05），而内脏AT显著低于男性（P < 0.01）。此外，内脏AT随着年龄的增长而增加，如在匹配的年龄组中所示。在两个性别群体中。与胰岛素敏感受试者相比，胰岛素抵抗受试者的特征在于较高的内脏脂肪组织（VAT）。此外，胰岛素抵抗受试者的概况显示肩/颈部AT更多，但上肢AT较少。基于T1的全身AT曲线的标准化评估-加权MRI为个体间比较体脂分布提供了可靠的基础，并可快速可靠地定量全身脂肪组织和不同AT组分（如皮下和内脏脂肪）的分布在不同的身体区域。标准化特征的差异可能有助于早期识别代谢紊乱风险人群，因为AT的数量和分布预计在代谢疾病的发病机制中发挥重要作用。(c)2005 Wiley-Liss，Inc.
Purpose: To assess standardized whole body adipose tissue topography in a cohort of subjects at an increased risk for type 2 diabetes and to compare fat distribution in subgroups regarding anthropometric (age, body mass index [BMI]) and metabolic parameters (insulin sensitivity).Materials and Methods: A total of 80 volunteers (40 females, 40 males) underwent T1-weighted MR imaging of the entire body. Standardized adipose tissue (AT) profiles were calculated considering the different body structure of the participants. The measured data were interpolated to a defined number of sampling points enabling a direct comparison of the profiles independent on body structure. Resulting mean profiles and region-dependent standard deviations of four age groups and three BMI-groups were compared for females and males. Correlations between insulin sensitivity and body fat distribution were analyzed.Results: Reliable adipose tissue profiles could be obtained from all volunteers. In BMI-matched subgroups, females show significant higher AT and subcutaneous abdominal AT (P < 0.05 both), but lower visceral AT (P < 0.01) compared to the males. Furthermore, visceral AT increases with age, as shown in the matched age groups. In both gender groups. insulin-resistant subjects are characterized by higher visceral adipose tissue (VAT) compared to insulin-sensitive subjects. In addition, profiles of insulin-resistant subjects show more AT in the shoulder/neck region but less AT in the upper extremities.Conclusion: Standardized assessment of whole body AT profiles based on T1-weighted MRI provides a reliable basis for interindividual comparison of the body fat distribution and allows a fast and reliable quantification of total body adipose tissue and the distribution of different AT components as subcutaneous and visceral fat in different body regions. Differences in standardized profiles might enable an early identification of people at risk of metabolic disorders, as not only the amount but also the distribution of AT is expected to play an essential role in the pathogenesis of metabolic diseases. (c) 2005 Wiley-Liss, Inc.