CSF hypocretin levels are normal in Huntington's disease patients.
CSF hypocretin levels are normal in Huntington's disease patients.
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亨廷顿病患者的脑脊液下丘脑分泌素水平正常。
DOI：
10.1093/sleep/28.12.1607
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发表时间：
2005
期刊：
影响因子：
5.6
通讯作者：
Mignot,Emmanuel
中科院分区：
文献类型：
--
作者：
Gaus,StephanieE;Lin,Ling;Mignot,Emmanuel
《睡眠》，第28卷，第12期，2005年，可能是因为补偿机制。这一结果与大鼠研究一致，表明神经元数量需要减少73%才能将CSF hcrt-1水平降低50%。HD患者的睡眠障碍是否可能是由于hcrt表达细胞的这种适度损失尚不清楚;这些障碍也不一定与运动障碍有关，11因此，其病因仍不清楚。在发作性睡病中，hcrt的损失归因于细胞体的损失。10尽管存在萎缩的含hcrt的细胞体7提示活动性变性，但hcrt细胞死亡的特异性仍需要在HD中建立。在小鼠和其他模型中的进一步研究可能会阐明在某些物种或实验条件下hcrt细胞对HD过程的优先敏感性问题。这个问题不仅对HD专家感兴趣，而且对嗜睡症领域也感兴趣，因为hcrt细胞在这种疾病中也优先退化。
SLEEP, Vol. 28, No. 12, 2005 possibly because of compensatory mechanisms. This result is in agreement with rat studies indicating a need for a 73% decrease in neuronal population to decrease CSF hcrt-1 levels by 50%. 9 Whether sleep disturbances in HD may result from this modest loss of hcrt-expressing cells is unknown; these disturbances are also not necessarily related to dyskinesia, 11 thus, their etiology is remains unclear.In narcolepsy, loss of hcrt is attributed to loss of cell bodies. 10 Specificity of hcrt cell death still needs to be established in HD, although the presence of atrophic hcrt-containing cell bodies7 suggests active degeneration. Further studies in mice and other models may shed light on the question of preferential sensitivity of hcrt cells to the HD process in some species or experimental conditions. This question is of interest not only for HD specialists, but also to the field of narcolepsy, as hcrt cells also preferentially degenerate in this disorder.