ConSite: web-based prediction of regulatory elements using cross-species comparison
ConSite: web-based prediction of regulatory elements using cross-species comparison
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DOI：
10.1093/nar/gkh372
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发表时间：
2004-07-01
影响因子：
14.9
通讯作者：
Lenhard, B
中科院分区：
文献类型：
--
作者：
Sandelin, A;Wasserman, WW;Lenhard, B
ConSite是一个用户友好的，基于网络的工具，用于寻找基因组序列中的顺式调控元件。预测是基于高质量的转录因子模型和跨物种比较过滤（系统发育足迹）生成的结合位点预测的整合。通过纳入进化的限制，选择性增加了一个数量级相比，单序列分析。ConSite提供了几个独特的功能，包括一个交互式专家系统，用于检索正向调节序列。构成ConSite服务基础的编程模块和生物数据库可供研究界免费使用。ConSite可在http：/www.phylofoot.org/consite上获得。
ConSite is a user-friendly, web-based tool for finding cis-regulatory elements in genomic sequences. Predictions are based on the integration of binding site prediction generated with high-quality transcription factor models and cross-species comparison filtering (phylogenetic footprinting). By incorporating evolutionary constraints, selectivity is increased by an order of magnitude as compared to single-sequence analysis. ConSite offers several unique features, including an interactive expert system for retrieving orthologous regulatory sequences. Programming modules and biological databases that form the foundation of the ConSite service are freely available to the research community. ConSite is available at http:/www.phylofoot.org/consite.