Long-term outcome of hypofractionated radiotherapy to the whole breast of Japanese women after breast-conserving surgery.
Long-term outcome of hypofractionated radiotherapy to the whole breast of Japanese women after breast-conserving surgery.
复制标题
日本女性保乳手术后全乳房大分割放疗的长期结果。
DOI：
10.1007/s12282-012-0345-2
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发表时间：
2014
期刊：
影响因子：
4
通讯作者：
Hiratsuka J
中科院分区：
文献类型：
--
作者：
Ishihara T;Yoden E;Konishi K;Nagase N;Yoshida K;Kurebayashi J;Sonoo H;Murashima N;Sasaki R;Hiratsuka J
背景在日本，对于保乳手术（BCS）后全乳大分割放射治疗的长期结果还没有报道。我们报告了我们机构对日本女性大分割放疗的有效性和安全性进行评估的结果。方法回顾性审查了327例患者病历中的数据。患者于2003年1月至2006年12月在川崎医科大学医院接受大分割放射治疗，并随访3年以上。中位年龄为54岁（年龄范围为28-80岁）。全乳照射总剂量为42.56戈伊/16 fx，并加强照射至阳性边缘。辅助治疗包括化疗和/或激素治疗，并给予300例患者，根据他们的阶段或病理findings. ResultsFollow随访期为21至92个月，中位随访期为60个月。5年随访时，总生存率、病因特异性生存率、无复发生存率和局部控制率分别为96.0%、97.5%、95.3%和99.7%。5例患者发生2级放射性肺炎。17例患者发生2级放射性皮炎。严重的晚期并发症没有observed.ConclusionsIn我们的研究中，大分割放疗导致良好的效果，没有严重的毒性。我们相信BCS后的大分割放射治疗对日本女性是安全有效的治疗方法。
BackgroundIn Japan, there are still no reports of long-term outcome for hypofractionated radiotherapy to the whole breast after breast-conserving surgery (BCS). We report our institution’s results from evaluation of the efficacy and safety of hypofractionated radiotherapy for Japanese women.MethodsData in the medical records of 327 patients were retrospectively reviewed. The patients were treated with hypofractionated radiotherapy between January 2003 and December 2006 at the Kawasaki Medical School Hospital and were followed for more than 3 years. The median age was 54 years old (the age range was 28–80 years). The whole breast was irradiated with a total dose of 42.56 Gy/16 fx with boost irradiation to positive margins. Adjuvant therapy consisted of chemotherapy and/or hormone therapy and was administered to 300 patients, based on their stage or pathological findings.ResultsFollow-up periods ranged from 21 to 92 months; the median follow-up period was 60 months. At 5-year follow-up, overall survival, cause-specific survival, relapse-free survival, and local control were 96.0, 97.5, 95.3, and 99.7% respectively. Grade 2 radiation pneumonitis occurred in five patients. Grade 2 radiation dermatitis occurred in 17 patients. Severe late complications were not observed.ConclusionsIn our study, hypofractionated radiotherapy led to good results without severe toxicity. We believe hypofractionated radiotherapy after BCS is safe and efficient treatment for Japanese women.