Metabolite transporters of the plant peroxisomal membrane: known and unknown.
Metabolite transporters of the plant peroxisomal membrane: known and unknown.
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DOI：
10.1007/978-94-007-6889-5_10
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发表时间：
2013-01-01
影响因子：
--
通讯作者：
Theodoulou, Frederica L
中科院分区：
文献类型：
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作者：
Linka, Nicole;Theodoulou, Frederica L
植物过氧化物酶体的研究取得了巨大进展，揭示了植物过氧化物酶体具有意想不到的代谢功能。除了光呼吸和脂类代谢外，过氧化物酶体在植物激素的合成、病原菌防御、衰老相关过程、生物素和类异戊二烯的合成、尿酸盐、多胺、亚硫酸盐、叶绿醌、挥发性苯丙氨酸和支链氨基酸的代谢等许多代谢和信号传导途径中发挥着重要作用。这些过氧化物酶体途径需要与其他细胞隔室，包括质体，线粒体和胞质溶胶的相互作用。因此，相当数量的底物、中间体、终产物和辅因子必须穿梭于过氧化物酶体膜。然而，我们对它们的膜通道的了解仍然相当有限。本文综述了过氧化物酶体与其他细胞室连接所需的溶质转运过程。此外，我们讨论了已知的和尚未被定义的转运蛋白介导这些代谢交换过氧化物酶体双层。
Tremendous progress in plant peroxisome research has revealed unexpected metabolic functions for plant peroxisomes. Besides photorespiration and lipid metabolism, plant peroxisomes play a key role in many metabolic and signaling pathways, such as biosynthesis of phytohormones, pathogen defense, senescence-associated processes, biosynthesis of biotin and isoprenoids, and metabolism of urate, polyamines, sulfite, phylloquinone, volatile benzenoids, and branched chain amino acids. These peroxisomal pathways require an interplay with other cellular compartments, including plastids, mitochondria, and the cytosol. Consequently, a considerable number of substrates, intermediates, end products, and cofactors have to shuttle across peroxisome membranes. However, our knowledge of their membrane passage is still quite limited. This review describes the solute transport processes required to connect peroxisomes with other cell compartments. Furthermore, we discuss the known and yet-to-be-defined transport proteins that mediate these metabolic exchanges across the peroxisomal bilayer.