Psoriasis decreases the anti-oxidation and anti-inflammation properties of high-density lipoprotein
Psoriasis decreases the anti-oxidation and anti-inflammation properties of high-density lipoprotein
复制标题
牛皮癣降低高密度脂蛋白的抗氧化和抗炎特性
DOI：
10.1016/j.bbalip.2014.09.008
复制
发表时间：
2014-12-01
影响因子：
4.8
通讯作者：
Li, Yuzhen
中科院分区：
文献类型：
--
作者：
He, Lei;Qin, Shucun;Li, Yuzhen
牛皮癣是一种慢性炎症性皮肤病，与血脂异常和脂蛋白潜在功能损伤有关。这项横断面研究旨在表征 25 名银屑病患者和 25 名年龄和性别匹配的健康对照者血浆脂蛋白的生物活性。在本研究中，我们发现与健康对照者相比，银屑病组的血浆高密度脂蛋白 (HDL) 胆固醇水平降低。血浆、HDL3 和低密度脂蛋白 (LDL) 中的丙二醛 (MDA) 含量增加。然而，银屑病患者血浆对氧磷酶-1（PON-1）活性降低，且与银屑病面积和严重程度指数（PASI）呈负相关。此外，银屑病患者血浆中肿瘤坏死因子-cc (TNF-α) 和白细胞介素-6 (11.-6) 的水平升高，且与 PASI 呈正相关。高敏 C 反应蛋白 (hs-CRP) 在银屑病中升高，但与 PASI 相关时未达到显着性。体外测试显示，从银屑病患者分离的HDL3功能显着下降，通过四种独立的方式进行评估，即（1）防止LDL氧化，（2）抑制肿瘤坏死因子-cc（TNF-a）诱导的单核细胞粘附于内皮细胞，（3）预防氧化低密度脂蛋白（ox-LDL）诱导的单核细胞迁移，以及（4）保护内皮细胞免受TNF-α诱导的凋亡。此外，从银屑病患者中分离出的低密度脂蛋白的促氧化和促炎特性有所增加。总之，HDL 和 LDL 中银屑病脂蛋白的生物活性均受损，这可能提供银屑病与心血管疾病之间的联系。 (C) 2014 Elsevier B.V. 保留所有权利。
Psoriasis is a chronic inflammatory skin disease, which has been linked to dyslipidemia with potential functional impairment of lipoproteins. This cross-sectional study was designed to characterize the biological activities of plasma lipoproteins in 25 patients with psoriasis and 25 age-and sex-matched healthy controls.In the present study, we found that plasma levels of high-density lipoprotein (HDL) cholesterol were decreased in the psoriasis group compared to healthy controls. The malondialdehyde (MDA) content in plasma, in HDL3 and in low-density lipoprotein (LDL) were increased. However, the activity of plasma paraoxonase-1 (PON-1) decreased in psoriasis and negatively correlated with the psoriasis area and severity index (PASI). Moreover, plasma levels of tumor necrosis factor-cc (TNF-alpha) and interleukin-6 (11.-6) were increased in psoriasis and positively correlated with the PASI. High-sensitivity C-reactive protein (hs-CRP) was increased in psoriasis, but did not reach significance when correlated with PASI. In vitro tests displayed that the functionalities of HDL3 isolated from psoriatic patients significantly decreased, which were assessed in four independent ways, namely (1) protection against LDL oxidation, (2) inhibition of tumor necrosis factor-cc (TNF-a) induced monocyte adherence to endothelial cells, (3) prevention of oxidized low density lipoprotein (ox-LDL) induced monocyte migration, and (4) protection of endothelial cells from TNF-alpha induced apoptosis. Further, pro-oxidative and pro-inflammatory properties of LDL isolated from psoriatic patients were increased. In conclusion, the biological activities of psoriatic lipoproteins are impaired in both HDL and LDL, which may provide a link between psoriasis and cardiovascular disease. (C) 2014 Elsevier B.V. All rights reserved.