Liver intravoxel incoherent motion (IVIM) magnetic resonance imaging: a comprehensive review of published data on normal values and applications for fibrosis and tumor evaluation
Liver intravoxel incoherent motion (IVIM) magnetic resonance imaging: a comprehensive review of published data on normal values and applications for fibrosis and tumor evaluation
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DOI：
10.21037/qims.2017.02.03
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发表时间：
2017-02-01
影响因子：
2.8
通讯作者：
Wang, Yi Xiang J.
中科院分区：
文献类型：
--
作者：
Li, Yao T.;Cercueil, Jean-Pierre;Wang, Yi Xiang J.
本文对肝脏体素内非相干运动（IVIM）磁共振成像（MRI）技术及其应用进行了综述。报告了异质数据。IVIM参数在一定程度上依赖于磁场强度。观察到3 T时的Dslow（D）值低于1.5 T时，3 T时的灌注分数（PF）值高于1.5 T时。B值数量的增加与IVIM参数测量准确度的增加相关。以目前的技术水平，IVIM技术尚不能检测早期肝纤维化和诊断肝纤维化分级，也不能区分肝肿瘤。尽管IVIM参数显示出用于肿瘤治疗监测的前景，但到目前为止，PF和Dfast（D *）如何将诊断价值添加到Dslow或表观扩散系数（ADC）仍不清楚。本文表明，最先进的IVIM MR技术仍然不能提供可靠的测量肝脏。有必要对测量稳健性进行更多的研究，因为它们对于证明对患者的后续临床研究是必要的。
A comprehensive literature review was performed on liver intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) technique and its applications. Heterogeneous data have been reported. IVIM parameters are magnetic field strength dependent to a mild extent. A lower Dslow (D) value at 3 T than at 1.5 T and higher perfusion fraction (PF) value at 3 T than at 1.5 T were noted. An increased number of b values are associated with increased IVIM parameter measurement accuracy. With the current status of art, IVIM technique is not yet capable of detecting early stage liver fibrosis and diagnosing liver fibrosis grades, nor can it differentiate liver tumors. Though IVIM parameters show promise for tumor treatment monitoring, till now how PF and Dfast (D*) add diagnostic value to Dslow or apparent diffusion coefficient (ADC) remains unclear. This paper shows the state-of-art IVIM MR technique is still not able to offer reliable measurement for liver. More works on the measurement robustness are warranted as they are essential to justify follow-up clinical studies on patients.