General principles of antimicrobial therapy.
General principles of antimicrobial therapy.
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DOI：
10.4065/mcp.2010.0639
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发表时间：
2011-02
影响因子：
8.9
通讯作者：
Edson RS
中科院分区：
文献类型：
--
作者：
Leekha S;Terrell CL;Edson RS
抗微生物剂是全世界最广泛使用的治疗药物之一，但通常使用不当。处方抗菌药物治疗时的重要考虑因素包括获得准确的感染诊断;了解经验性和确定性治疗之间的差异;确定在必要的最短时间内转换为窄谱、经济有效的口服药物的机会;了解抗菌药物特有的药物特性（如感染部位的药效学和功效）;考虑影响抗微生物活性的宿主特征;进而认识到抗微生物剂对宿主的不良影响。了解抗菌药物管理的重要性，了解何时咨询传染病专家寻求指导，以及能够识别不需要抗菌药物治疗的情况也很重要。通过遵循这些一般原则，所有执业医生都应该能够以负责任的方式使用抗菌药物，使患者个人和社区受益。
Antimicrobial agents are some of the most widely, and often injudiciously, used therapeutic drugs worldwide. Important considerations when prescribing antimicrobial therapy include obtaining an accurate diagnosis of infection; understanding the difference between empiric and definitive therapy; identifying opportunities to switch to narrow-spectrum, cost-effective oral agents for the shortest duration necessary; understanding drug characteristics that are peculiar to antimicrobial agents (such as pharmacodynamics and efficacy at the site of infection); accounting for host characteristics that influence antimicrobial activity; and in turn, recognizing the adverse effects of antimicrobial agents on the host. It is also important to understand the importance of antimicrobial stewardship, to know when to consult infectious disease specialists for guidance, and to be able to identify situations when antimicrobial therapy is not needed. By following these general principles, all practicing physicians should be able to use antimicrobial agents in a responsible manner that benefits both the individual patient and the community.
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影响因子：
5.9
作者：
del Real, Gonzalo Alvarez;Rose, Mark E.;Arroliga, Mercedes E.
通讯作者：
Arroliga, Mercedes E.
影响因子：
11.8
作者：
Dunbar, LM;Wunderink, RG;Kahn, JB
通讯作者：
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影响因子：
11.8
作者：
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通讯作者：
Houck, PM
DOI：
10.1001/archpediatrics.2009.188
发表时间：
2009-11-01
影响因子：
--
作者：
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通讯作者：
Hu, Dale J.
影响因子：
11.8
作者：
Howden, BP;Ward, PB;Grayson, ML
通讯作者：
Grayson, ML