Effect of Interleukin-2 Level and Genetic Variants on Coronary Artery Disease
Effect of Interleukin-2 Level and Genetic Variants on Coronary Artery Disease
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IL-2 水平和遗传变异对冠状动脉疾病的影响
DOI：
10.1007/s10753-013-9659-2
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发表时间：
2013-12-01
期刊：
影响因子：
5.1
通讯作者：
Wu, Zonggui
中科院分区：
文献类型：
--
作者：
Ding, Ru;Gao, Wenwu;Wu, Zonggui
炎症在动脉粥样硬化和冠状动脉疾病（CAD）的发展中起着重要作用。白细胞介素-2 （IL-2）是一种促炎细胞因子，可诱导T细胞增殖。本研究旨在从基因多态性角度和血清水平角度了解IL-2在冠心病发生发展中的作用。在692例冠心病患者和723例健康对照中检测了IL-2 -330T/G和+114T/G多态性。比较了这两种多态性的IL-2表达。分析冠心病患者及对照组血清IL-2水平。数据显示，冠心病患者IL-2 -330GG基因型的患病率明显高于对照组（p = 5.1 × 10(-6)）。功能分析显示IL-2 -330GG基因型患者血清IL-2水平高于TG和TT基因型患者（p < 0.01）。进一步分析研究对象血清IL-2水平，结果显示CAD患者IL-2水平明显高于健康对照组（p < 0.01）。三支血管病变组IL-2水平高于单支血管病变组（p < 0.05）。提示IL-2多态性可能通过升高蛋白表达影响冠心病易感性，血清IL-2水平可能与该病的发生发展密切相关。
Inflammation plays important roles in the development of atherosclerosis and coronary artery disease (CAD). Interleukin-2 (IL-2) is a proinflammatory cytokine and induces proliferation of T cells. The aim of the study was to understand the effect of IL-2 on the development of CAD from genetic polymorphism perspective and serum level perspective. IL-2 -330T/G and +114T/G polymorphisms were tested in 692 CAD cases and 723 healthy controls. IL-2 expression of these two polymorphisms was compared. Serum level of IL-2 in CAD patients and controls was analyzed. Data showed that prevalence of IL-2 -330GG genotype was significantly increased in CAD than in controls (p = 5.1 x 10(-6)). Function analysis revealed that subjects carrying IL-2 -330GG genotype had higher serum level of IL-2 than those with TG or TT genotypes (p < 0.01). Serum level of IL-2 in the study subjects was further analyzed, and results showed that CAD patients had significantly increased IL-2 level than healthy controls (p < 0.01). Also, cases with three vessels affected were observed to have higher IL-2 level than cases with one vessel affected (p < 0.05). These data suggested IL-2 polymorphism could affect the susceptibility to CAD by elevating protein expression, and serum level of IL-2 may be closed correlated with the development and progression of this disease.