Burden of Rotavirus and Enteric Bacterial Pathogens among Children under 5 Years of Age Hospitalized with Diarrhea in Suburban and Rural Areas in Kenya
Burden of Rotavirus and Enteric Bacterial Pathogens among Children under 5 Years of Age Hospitalized with Diarrhea in Suburban and Rural Areas in Kenya
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DOI：
10.7883/yoken.jjid.2016.398
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发表时间：
2017-07-01
影响因子：
2.2
通讯作者：
Ichinose, Yoshio
中科院分区：
文献类型：
--
作者：
Shah, Mohammad;Odoyo, Erick;Ichinose, Yoshio
这项横断面描述性研究旨在调查肯尼亚郊区和农村地区5岁以下腹泻儿童轮状病毒和肠道细菌感染的发病率。2011年8月至2013年12月期间，从位于郊区的基安布县医院（KCH）的722名儿童和位于肯尼亚西部农村地区的Mbita地区医院（MDH）的338名儿童中共获得了1，060份粪便标本。在1,060株轮状病毒中，A组轮状病毒分别在KCH和MDH的29.6%（214/722）和11.2%（38/338）粪便标本中检出。致泻性大肠杆菌（DEC）被认为是最常见的分离细菌病原体在两个研究领域（32.8%在KCH和44.1%在MDH）。在患者中观察到两种不同的混合感染模式（病毒/细菌和细菌/细菌）。在旱季观察到轮状病毒（17.6%，p = 0.001）和DEC（10.5%，p = 0.007）的感染率显著较高。我们的研究发现，在肯尼亚的郊区和农村地区，轮状病毒和DEC是儿童腹泻的主要原因，在旱季发病率较高。
This cross-sectional descriptive study aimed to investigate the incidence of rotavirus and enteric bacterial infections among children up to 5 years old with diarrhea living in suburban and rural areas of Kenya. Between August 2011 and December 2013, a total of 1,060 diarrheal fecal specimens were obtained from 722 children at Kiambu County Hospital (KCH), located in a suburban area, and from 338 children from Mbita District Hospital (MDH), located in a rural part of western Kenya. Of the 1,060 isolates, group A rotavirus was detected in 29.6% (214/722) and 11.2% (38/338) fecal specimens from KCH and MDH, respectively. Diarrheagenic Escherichia coli (DEC) was found to be the most frequently isolated bacterial pathogens in both study areas (32.8% at KCH and 44.1% at MDH). Two different mixed infection patterns (virus/bacteria and bacteria/bacteria) were observed among patients. A significantly higher infection rate of rotavirus (17.6%, p = 0.001) and DEC (10.5%, p = 0.007) were observed during the dry season. Our study found that in both suburban and rural settings in Kenya, rotavirus and DEC are the principal cause of pediatric diarrhea and exhibit higher incidence during the dry season.