PARATHYROID HORMONE-RESPONSIVE ADENYLATE-CYCLASE IN INDUCED TRANSPLANTABLE OSTEOGENIC RAT SARCOMA
PARATHYROID HORMONE-RESPONSIVE ADENYLATE-CYCLASE IN INDUCED TRANSPLANTABLE OSTEOGENIC RAT SARCOMA
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DOI：
10.1038/260436a0
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发表时间：
1976-01-01
期刊：
影响因子：
64.8
通讯作者：
MELICK, RA
中科院分区：
文献类型：
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作者：
MARTIN, TJ;INGLETON, PM;MELICK, RA
一个明显的悖论阻碍了对环磷酸腺苷在肿瘤发展和维持中的作用的准确评估。虽然细胞培养实验表明恶性转化与腺苷酸环化酶活性降低和细胞内环AMP水平降低有关1，2，但肿瘤体内研究的结果并非如此，在肿瘤体内研究中，已获得了一系列结果，从低3到正常4和升高5肿瘤细胞环AMP水平。我们在这里报告的发展，可移植的成骨肉瘤，保留了通过许多代甲状旁腺激素反应的腺苷酸环化酶，提供了一个系统，可用于评估的意义，甲状旁腺激素反应的腺苷酸环化酶的肿瘤细胞的生长和分化。
AN apparent paradox prevents accurate assessment of the role of cyclic AMP in the development and maintenance of tumours. Although cell culture experiments indicate that malignant transformation is associated with decreased adenylate cyclase activity and intracellular cyclic AMP levels1,2, the same is not true ofin vivostudies with tumours, in which a range of results have been obtained, from low3to normal4and elevated5tumour cell cyclic AMP levels. We report here the development of a transplantable osteogenic sarcoma which has retained through many generations a parathyroid hormone-responsive adenylate cyclase, providing a system which can be used to evaluate the significance of hormone-responsive adenylate cyclase for tumour cell growth and differentiation.