Requirement for the leukocyte-specific adapter protein SLP-76 for normal T-cell development
Requirement for the leukocyte-specific adapter protein SLP-76 for normal T-cell development
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DOI：
10.1126/science.281.5375.416
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发表时间：
1998-07-17
期刊：
影响因子：
56.9
通讯作者：
Koretzky, GA
中科院分区：
文献类型：
--
作者：
Clements, JL;Yang, B;Koretzky, GA
白细胞特异性适配分子SLP-76（含有76千顿的Src同源2结构域的白细胞蛋白）在受体连接后在酪氨酸残基上迅速磷酸化。SLP-76表达不足的小鼠由于早期胸腺生成阻滞而不含外周T细胞。巨噬细胞和自然杀伤细胞区室在SLP-76缺陷小鼠中是完整的，尽管这些谱系在野生型小鼠中表达SLP-76。因此，SLP-76适配蛋白是正常胸腺细胞发育所必需的，并且在t细胞前受体介导的信号转化为远端生化事件中起着至关重要的作用。
The Leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain-containing Leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor Ligation in several hematopoietically derived cell types. Mice made deficient for SLP-76 expression contained no peripheral T cells as a result of an early block in thymopoiesis. Macrophage and natural killer cell compartments were intact in SLP-76-deficient mice, despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter protein is required for normal-thymocyte development and plays a crucial role in translating signals mediated by pre-T cell receptors into distal biochemical events.