Post-prandial glucose excursions following four methods of bolus insulin administration in subjects with Type 1 diabetes
Post-prandial glucose excursions following four methods of bolus insulin administration in subjects with Type 1 diabetes
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DOI：
10.1046/j.1464-5491.2002.00685.x
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发表时间：
2002-04-01
影响因子：
3.5
通讯作者：
Garg, SK
中科院分区：
文献类型：
--
作者：
Chase, HP;Saib, SZ;Garg, SK
目的是为了确定是否一种方法的短效胰岛素推注是上级的其他方法在管理膳食高碳水化合物，热量和fat.Methods九个受试者接受连续皮下胰岛素输注使用赖脯胰岛素（Humanitin（R））同意消耗相同的膳食高碳水化合物，热量和脂肪的四个场合1周相隔。他们在随机分配的四种情况下接受相同剂量的餐时胰岛素，从餐前10分钟开始，单次大剂量，两次单独的大剂量，总剂量的一半（90分钟后的第二次），整个大剂量以方波（2小时内）或双波（70%为大剂量，30%为方波，2小时内）给予。在门诊用Hemacue（R）血糖仪分别于空腹后-60、-30 min、0时及以后每隔半小时测定血糖，连续6 h。结果空腹后90、120 min血糖变化最小（P
Aims To determine if one method of short-acting insulin bolus administration is superior to other methods in managing a meal high in carbohydrates, calories and fat.Methods Nine subjects receiving continuous subcutaneous insulin infusion using insulin lispro (Humalog(R)) agreed to consume the same meal high in carbohydrates, calories and fat on four occasions 1 week apart. They received the same dose of bolus insulin on each of the four occasions randomly assigned and beginning 10 min prior to the meal as either a single bolus, two separate boluses of one-half the same total dose (the second after 90 min), the entire bolus given as a square-wave (over 2 h) or a dual-wave (70% as a bolus and 30% as a square-wave over 2 h). Blood glucose levels were measured at -60 and -30 min and at zero time, and then every half-hour for 6 h using the Hemacue(R) in the out-patient clinic.Results Changes in blood glucose values from fasting were the lowest after 90 and 120 min (P