The mechanosensitivity of spinal sensory neurons following intraspinal injections of quisqualic acid in the rat.
The mechanosensitivity of spinal sensory neurons following intraspinal injections of quisqualic acid in the rat.
复制标题
大鼠椎管内注射使君子酸后脊髓感觉神经元的机械敏感性。
DOI：
10.1016/0304-3940(93)90656-6
复制
发表时间：
1993
影响因子：
2.5
通讯作者：
Park,SH
中科院分区：
文献类型：
--
作者：
Yezierski,RP;Park,SH
The mechanoreceptive properties of rat spinal sensory neurons were evaluated in segments adjacent to those injected with the excitatory amino acid agonist quisqualic acid. Following survival periods of 7–36 days cells recorded in quisqualate injected animals had an increased level of background activity, increased sensitivity to mechanical stimuli, and an increase in the duration of afterdischarge responses. It is suggested that a central mechanism that alters the functional state of neurons may be responsible for the sensory abnormalities, e.g. allodynia and hyperalgesia, that occur following excitotoxic induced cell death associated with ischemic and traumatic spinal cord injury.
