Sympathetic arousal moderates self-reported physiological arousal symptoms at baseline and physiological flexibility in response to a stressor in generalized anxiety disorder
Sympathetic arousal moderates self-reported physiological arousal symptoms at baseline and physiological flexibility in response to a stressor in generalized anxiety disorder
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DOI：
10.1016/j.biopsycho.2009.12.007
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发表时间：
2010-03-01
影响因子：
2.6
通讯作者：
Newman, Michelle G.
中科院分区：
文献类型：
--
作者：
Fisher, Aaron J.;Granger, Douglas A.;Newman, Michelle G.
与对照组相比，广泛性焦虑症（GAD）患者在实验室应激反应中往往不能表现出预期的生理唤醒变化。然而，GAD患者经常报告有明显的主观觉醒。我们试图评估GAD患者和对照组的交感神经唤醒程度，以及这种唤醒对自我报告的生理唤醒和对情绪挑战的反应的影响。基线交感神经唤醒程度调节了基线时非共病GAD患者的生理唤醒自我报告，因此在该组中，与对照组相比，较高水平的交感神经唤醒可预测生理唤醒升高的报告。总体而言，GAD患者在应对情绪挑战时的唤醒没有显着变化。然而，基础交感神经唤醒调节程度的变化，这样的非共病GAD参与者低基线交感神经唤醒表现出类似于对照组的觉醒变化的压力。基础交感神经唤醒调节了基线时自我报告的唤醒和对应激源的交感神经反应，这表明GAD具有重要的生理异质性，其中只有那些具有增强的紧张性交感神经唤醒的个体报告伴随症状并显示交感神经反应性降低。(C)2009爱思唯尔有限公司版权所有。
Compared to controls, individuals with generalized anxiety disorder (GAD) often fail to exhibit expected changes in physiological arousal in response to laboratory stressors. Nevertheless, individuals with GAD often report significant subjective arousal. We sought to assess the degree of sympathetic arousal in individuals with GAD and controls and the impact such arousal had on self-reported physiological arousal and response to an emotional challenge. Degree of baseline sympathetic arousal moderated the self-report of physiological arousal in non-comorbid GAD at baseline such that within this group, higher levels of sympathetic arousal predicted reports of heightened physiological arousal compared to controls. Overall, individuals with GAD exhibited no significant changes in arousal in response to the emotional challenge. However, basal sympathetic arousal moderated degree of change such that non-comorbid GAD participants low in baseline sympathetic arousal exhibited changes in arousal similar to controls in response to the stressor. That basal sympathetic arousal moderated both self-reported arousal at baseline and sympathetic response to a stressor suggests important physiological heterogeneity in GAD, wherein only those individuals with heightened tonic sympathetic arousal report accompanying symptoms and display diminished sympathetic reactivity. (C) 2009 Elsevier B.V. All rights reserved.