Malaria in India: The Center for the Study of Complex Malaria in India
Malaria in India: The Center for the Study of Complex Malaria in India
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DOI：
10.1016/j.actatropica.2011.11.008
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发表时间：
2012-03-01
期刊：
影响因子：
2.7
通讯作者：
Valecha, Neena
中科院分区：
文献类型：
--
作者：
Das, Aparup;Anvikar, Anupkumar R.;Valecha, Neena
疟疾是印度的一个主要公共卫生问题，也是东南亚总体疟疾负担的主要原因之一。印度国家病媒传播疾病控制方案报告，2009年有类似的160万例疟疾病例和1100例疟疾死亡。一些专家认为，这是一个严重的低估，每年疟疾病例的实际数量可能要高出9至50倍。与疟疾有关的死亡率被低估了约13倍。作出这些估计的难度因以下因素而进一步加剧：㈠疟疾生态流行病学特征变化很大，㈡多种疟原虫和按蚊病媒的传播和重叠，㈢抗疟药物抗药性和杀虫剂抗药性的增加，以及㈣气候变化对这些变量中每一个的影响。简单地说，印度的疟疾负担是复杂的。在这里，我们描述了印度复杂疟疾研究中心（CSCMi）的计划，该中心是位于世界疟疾流行地区的10个国际疟疾研究卓越中心（ICEMR）之一，最近由美国国立卫生研究院过敏和传染病研究所资助。CSCMi是印度和美国科学家之间的密切伙伴关系，旨在解决我们对印度疟疾复杂性的理解方面的主要差距，包括流行病学，病媒生物学和控制，耐药性和寄生虫基因组学的变化模式。我们希望这种将临床和实地研究与实验室、分子和基因组方法相结合的多学科方法将为印度的疟疾控制和预防提供强有力的组合。(C)2011爱思唯尔有限公司版权所有。
Malaria is a major public health problem in India and one which contributes significantly to the overall malaria burden in Southeast Asia. The National Vector Borne Disease Control Program of India reported similar to 1.6 million cases and 1100 malaria deaths in 2009. Some experts argue that this is a serious underestimation and that the actual number of malaria cases per year is likely between 9 and 50 times greater. with an approximate 13-fold underestimation of malaria-related mortality. The difficulty in making these estimations is further exacerbated by (i) highly variable malaria eco-epidemiological profiles, (ii) the transmission and overlap of multiple Plasmodium species and Anopheles vectors, (iii) increasing antimalarial drug resistance and insecticide resistance, and (iv) the impact of climate change on each of these variables. Simply stated, the burden of malaria in India is complex. Here we describe plans for a Center for the Study of Complex Malaria in India (CSCMi), one of ten International Centers of Excellence in Malaria Research (ICEMRs) located in malarious regions of the world recently funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health. The CSCMi is a close partnership between Indian and United States scientists, and aims to address major gaps in our understanding of the complexity of malaria in India, including changing patterns of epidemiology, vector biology and control, drug resistance, and parasite genomics. We hope that such a multidisciplinary approach that integrates clinical and field studies with laboratory, molecular, and genomic methods will provide a powerful combination for malaria control and prevention in India. (C) 2011 Elsevier B.V. All rights reserved.