RhoA-inhibiting NSAIDs promote axonal myelination after spinal cord injury.
RhoA-inhibiting NSAIDs promote axonal myelination after spinal cord injury.
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DOI：
10.1016/j.expneurol.2011.06.018
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发表时间：
2011-10
影响因子：
5.3
通讯作者：
Li, Shuxin
中科院分区：
文献类型：
--
作者：
Xing, Bin;Li, Hui;Wang, Hongyu;Mukhopadhyay, Dhriti;Fisher, Daniel;Gilpin, Christopher J.;Li, Shuxin
Nonsteroidal anti-inflammatory drugs (NSAIDs) are extensively used to relieve pain and inflammation in humans via cyclooxygenase inhibition. Our recent research suggests that certain NSAIDs including ibuprofen suppress intracellular RhoA signal and improve significant axonal growth and functional recovery following axonal injury in the CNS. Several NSAIDs have been shown to reduce generation of amyloid-beta42 peptide via inactivation of RhoA signal, supporting potent RhoA-repressing function of selected NSAIDs. In this report, we demonstrate that RhoA-inhibiting NSAIDs ibuprofen and indomethacin dramatically reduce cell death of oligodendrocytes in cultures or along the white matter tracts in rats with a spinal cord injury. More importantly, we demonstrate that treatments with the RhoA-inhibiting NSAIDs significantly increase axonal myelination along the white matter tracts following a traumatic contusion spinal cord injury. In contrast, non-RhoA-inhibiting NSAID naproxen does not have such an effect. Thus, our results suggest that RhoA inactivation with certain NSAIDs benefits recovery of injured CNS axons not only by promoting axonal elongation, but by enhancing glial survival and axonal myelination along the disrupted axonal tracts. This study, together with previous reports, supports that RhoA signal is an important therapeutic target for promoting recovery of injured CNS and that RhoA-inhibiting NSAIDs provide great therapeutic potential for CNS axonal injuries in adult mammals.
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影响因子：
4.2
作者：
Brabeck, C;Beschorner, R;Schwab, JM
通讯作者：
Schwab, JM
影响因子：
5.3
作者：
Bertrand, J;Winton, MJ;McKerracher, L
通讯作者：
McKerracher, L
影响因子：
5.3
作者：
Fournier, AE;Takizawa, BT;Strittmatter, SM
通讯作者：
Strittmatter, SM
影响因子：
82.9
作者：
Crowe, MJ;Bresnahan, JC;Beattie, MS
通讯作者：
Beattie, MS
DOI：
10.1523/jneurosci.3174-09.2010
发表时间：
2010-02-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cao Q;He Q;Wang Y;Cheng X;Howard RM;Zhang Y;DeVries WH;Shields CB;Magnuson DS;Xu XM;Kim DH;Whittemore SR
通讯作者：
Whittemore SR