Auditory and visual P300 event related potentials are not altered in medically and psychiatrically normal chronic marihuana users.
Auditory and visual P300 event related potentials are not altered in medically and psychiatrically normal chronic marihuana users.
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医学和精神正常的长期大麻使用者的听觉和视觉 P300 事件相关电位不会改变。
DOI：
10.1016/0024-3205(95)00199-g
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发表时间：
1995
期刊：
影响因子：
6.1
通讯作者：
Soucair,M
中科院分区：
文献类型：
--
作者：
Patrick,G;Straumanis,JJ;Struve,FA;Nixon,F;Fitz-Gerald,MJ;Manno,JE;Soucair,M
使用事件相关电位，特别是认知或 P300 诱发电位，作为 THC 使用的中枢神经系统影响的测量的尝试并不常见，并且产生了不一致的结果。我们发表了一项试点研究，其中与非使用者相比，使用 THC 的精神病患者的听觉 P300 潜伏期显着延长，振幅降低。由于精神科诊断和药物效应无法控制，我们对通过极其严格的排除标准和筛选程序选择的医学和精神正常受试者重复了这项研究。未检测到 THC 用户和对照之间的 P300 延迟差异。对于所有受试者，THC 用户均表现出听觉和视觉 P300 振幅降低。然而，当 THC 用户和对照组之间的年龄差异被消除时，所有显着的 P300 振幅差异也被消除。讨论了在 THC 研究中使用精神病患者的污染影响，并强调了在神经生理滥用药物效应研究中使用仔细筛选的正常受试者的重要性。
Attempts to use Event Related Potentials, particularly the cognitive or P300 evoked potential, as measures of CNS effects of THC use have been infrequent and have produced inconsistent results. We published a pilot study in which psychiatric patient THC users had significantly prolonged auditory P300 latencies and reduced amplitudes as contrasted with non-users. Because psychiatric diagnoses and medication effects could not be controlled, we repeated the study with medically and psychiatrically normal subjects selected with extremely stringent exclusion criteria and screening procedures. P300 latency differences between THC users and controls were not detected. Using all subjects, THC users displayed reduced auditory and visual P300 amplitudes. However, when age differences between THC users and controls were removed, all significant P300 amplitude differences were removed as well. The contaminating effect of using psychiatric patients in THC research is discussed and the importance of using carefully screened normal subjects in studies of neurophysiological abuse drug effects is stressed.
长期使用大麻对选择性注意力的影响：一项与事件相关的潜力研究
影响因子：
3.6
作者：
N. Solowij;P. Michie;A. Fox
通讯作者：
A. Fox
乙醇和大麻对记忆检索范式中事件相关电位的影响。
DOI：
--
发表时间：
1977
期刊：
Electroencephalography and Clinical Neurophysiology
影响因子：
--
作者：
W. Roth;J. Tinklenberg;B. S. Kopell
通讯作者：
B. S. Kopell
人类大麻研究中的脑电图和诱发电位方法：历史回顾和未来趋势
影响因子：
3.8
作者：
F. Struve;J. Straumanis
通讯作者：
J. Straumanis