Ca2+ imaging of self and other in medial prefrontal cortex during social dominance interactions in a tube test.
Ca2+ imaging of self and other in medial prefrontal cortex during social dominance interactions in a tube test.
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在试管试验中，在社会优势相互作用期间，自我和其他人的自我成像和其他成像。
DOI：
10.1073/pnas.2107942119
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发表时间：
2022-08-02
影响因子：
11.1
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中科院分区：
文献类型：
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对社会神经科学日益增长的兴趣要求发展和完善社会行为范式，并对一个大脑中的神经活动可能反映自我或他人的行为活动或两个相互作用的个体中的每一个的活动的方式进行新颖的分析。本研究记录了一种方法来分析这种相互作用的社会优势遇到啮齿动物之间。动物之间的社会支配相互作用的研究提供了一个窗口，在建立支配等级的决策，并有机会检查在某些神经遗传性疾病中观察到的社会行为的变化。竞争性的社会互动，如广泛使用的试管测试，反映了这种决策。以前的研究集中在支配和顺从动物的不同行为模式，被认为是调解这种遭遇的结果的努力行为的神经相关性，以及神经活动的中脑相关性。使用严格的互信息标准，我们现在报告说，神经反应记录与内镜钙成像在内侧前额叶皮层的边缘前区显示独特的相关性，以特定的优势相关的行为。动物间的分析揭示了细胞/行为的相关性，主要是与动物自己的行为或与其他动物的行为，或两种动物的一致行为（如推由一个和另一个抵制）。比较独特和一致的细胞有助于将反映动物自身或其他特定行为的细胞放电与反映联合行动的情况区分开来。这些相关性表明，在设计社会行为的神经生物学研究时，需要考虑社会互动的认知维度，而不仅仅是行为维度。这些可能被证明是有用的研究影响社会认知和社会参与的障碍，以及社会互动障碍的治疗。
Growing interest in social neuroscience requires the development and refinement of social behavior paradigms and novel analyses of the manner in which the neural activity in one brain may reflect the behavioral activity of self or of other, or the activity of each of two interacting individuals. This study documents an approach to analyze such interactions in a social dominance encounter between rodents. The study of social dominance interactions between animals offers a window onto the decision-making involved in establishing dominance hierarchies and an opportunity to examine changes in social behavior observed in certain neurogenetic disorders. Competitive social interactions, such as in the widely used tube test, reflect this decision-making. Previous studies have focused on the different patterns of behavior seen in the dominant and submissive animal, neural correlates of effortful behavior believed to mediate the outcome of such encounters, and interbrain correlations of neural activity. Using a rigorous mutual information criterion, we now report that neural responses recorded with endoscopic calcium imaging in the prelimbic zone of the medial prefrontal cortex show unique correlations to specific dominance-related behaviors. Interanimal analyses revealed cell/behavior correlations that are primarily with an animal’s own behavior or with the other animal’s behavior, or the coincident behavior of both animals (such as pushing by one and resisting by the other). The comparison of unique and coincident cells helps to disentangle cell firing that reflects an animal’s own or the other’s specific behavior from situations reflecting conjoint action. These correlates point to a more cognitive rather than a solely behavioral dimension of social interactions that needs to be considered in the design of neurobiological studies of social behavior. These could prove useful in studies of disorders affecting social recognition and social engagement, and the treatment of disorders of social interaction.