Prepubertal gonadectomy reveals sex differences in approach-avoidance behavior in adult mice
Prepubertal gonadectomy reveals sex differences in approach-avoidance behavior in adult mice
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DOI：
10.1016/j.yhbeh.2019.104641
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发表时间：
2020-02-01
影响因子：
3.5
通讯作者：
Wilbrecht, Linda
中科院分区：
文献类型：
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作者：
Delevich, Kristen;Hall, Christopher D.;Wilbrecht, Linda
青春期是与身体、认知和情感成熟相关的发育期，也是多种精神疾病出现性别偏见的时期。虽然青春期的开始标志着青春期的开始，但目前尚不清楚青春期性腺激素的上升是否会在接近回避行为中产生性别差异，这可能会影响精神上的脆弱性。为了研究青春期发育对成年行为的影响，我们在青春期开始之前切除了雄性和雌性小鼠的性腺或进行了假手术，并评估了成年后气味引导觅食任务的表现和焦虑相关行为。我们观察到完整的成年雄性和雌性小鼠在觅食或焦虑相关行为上没有明显的性别差异，但在青春期开始之前切除性腺(GDX)的成年雄性和雌性小鼠之间发现了显著的差异。雄性GDX未能完成气味引导的觅食任务，行动减少，焦虑样行为增加，而雌性GDX则表现出相反的行为模式。这些数据表明，青春期可能会最小化而不是推动雄性和雌性小鼠接近回避表型的差异。
Adolescence is a developmental period that is associated with physical, cognitive, and affective maturation and a time when sex biases in multiple psychiatric diseases emerge. While puberty onset marks the initiation of adolescence, it is unclear whether the pubertal rise in gonadal hormones generates sex differences in approach-avoidance behaviors that may impact psychiatric vulnerability. To examine the influence of pubertal development on adult behavior, we removed the gonads or performed sham surgery in male and female mice just prior to puberty onset and assessed performance in an odor-guided foraging task and anxiety-related behaviors in adulthood. We observed no significant sex differences in foraging or anxiety-related behaviors between intact adult male and female mice but found significant differences between adult male and female mice that had been gonadectomized (GDX) prior to puberty onset. GDX males failed to acquire the odor-guided foraging task, showed reduced locomotion, and exhibited increased anxiety-like behavior, while GDX females showed the opposite pattern of behavior. These data suggest that puberty may minimize rather than drive differences in approach-avoidance phenotypes in male and female mice.