Neurobehavioral alterations in developing transgenic mice expressing TNF-alpha in the brain
Neurobehavioral alterations in developing transgenic mice expressing TNF-alpha in the brain
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DOI：
10.1006/brbi.1996.0013
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发表时间：
1996-06-01
影响因子：
15.1
通讯作者：
Aloe, L
中科院分区：
文献类型：
--
作者：
Fiore, M;Probert, L;Aloe, L
During development, neuronal circuitry and memory formation are associated with the synthesis and release of several biological mediators, including cytokines. Among the numerous cytokines, the role of tumor necrosis factor-alpha (TNF-alpha) in neurobehavioral development is largely unknown. Thus, the recently generated transgenic mice expressing murine TNF-alpha in the brain represent a valid animal model for investigating the role of TNF-alpha in neurobehavioral processes. Using these mice, we showed that an overexpression of murine TNF-alpha increases grooming in the novel object investigation test, decreases rearing as a reaction to novel olfactory cues, and produces a retardation of passive avoidance acquisition while enhancing the thermal response in the hot-plate test, a task regulated by both peripheral and central mechanisms. The possibility that these effects are associated with endogenous changes in concentration of the NGF, known to be modulated by TNF-alpha, is discussed. (C) 1996 Academic Press, Inc.
