Correlation of plasma and synovial fluid osteopontin with disease severity in knee osteoarthritis
Correlation of plasma and synovial fluid osteopontin with disease severity in knee osteoarthritis
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DOI：
10.1016/j.clinbiochem.2009.02.002
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发表时间：
2009-06-01
影响因子：
2.8
通讯作者：
Yuktanandana, Pongsak
中科院分区：
文献类型：
--
作者：
Honsawek, Sittisak;Tanavalee, Aree;Yuktanandana, Pongsak
目的：本研究的目的是检查原发性膝关节骨关节炎（OA）患者的血浆和滑液中的骨桥蛋白水平，并探讨其与疾病严重程度的关系。设计和方法：32例年龄53-83岁的膝关节OA患者和15名健康对照者参加了这项研究。拍摄膝关节前后位X线片，以确定受累膝关节的疾病严重程度。膝关节OA的影像学分级采用Kelling-Lawrence标准。结果：膝关节骨性关节炎患者血浆骨桥蛋白浓度显著高于健康对照组（168.8 ± 15.6 vs 67.2 ± 7.7 ng/mL，P
Objectives: The purposes of this study were to examine osteopontin levels in both plasma and synovial fluid of patients with primary knee osteoarthritis (OA) and to investigate their relationship with severity of the disease.Design and methods: Thirty-two patients aged 53-83 years with knee OA and 15 healthy controls were enrolled in this study. Anteroposterior knee radiographs were taken to determine the disease severity of the affected knee. The radiographic grading of OA in the knee was performed by using the Kellgren-Lawrence criteria. Osteopontin levels in the plasma and synovial fluid were measured using enzyme-linked immunosorbent assay.Results: The mean plasma osteopontin concentration of the knee OA patients was significantly higher compared with that of healthy controls (168.8 +/- 15.6 vs 67.2 +/- 7.7 ng/mL, P