Effects of capsaicin analogs on adrenal catecholamine secretion in rats.
Effects of capsaicin analogs on adrenal catecholamine secretion in rats.
复制标题
辣椒素类似物对大鼠肾上腺儿茶酚胺分泌的影响。
DOI：
10.1016/0024-3205(94)00793-4
复制
发表时间：
1994
期刊：
影响因子：
6.1
通讯作者：
Kazuo Iwai
中科院分区：
文献类型：
--
作者：
Tatsuo Watanabe;Teruo Kawada;Toshio Kato;Tsutomu Harada;Kazuo Iwai
为了研究辣椒素的结构、辣度和产热作用之间的关系，合成了一系列具有饱和酰基（七烷基到二十烷基香草酰胺）的辣椒素类似物。比较了两种化合物在麻醉大鼠肾上腺儿茶酚胺分泌15 min后的刺激性和产热作用（655 nmol/kg, iv）。在类似物的酰基链长上，壬烷基对十八烷基香草酰胺引起肾上腺儿茶酚胺分泌强烈，而七烷基香草酰胺和二十烷基香草酰胺引起肾上腺儿茶酚胺分泌弱或无反应。除庚烷基香草酰胺外的刺激性类似物和除二十烷基香草酰胺外的非刺激性类似物均有较强的肾上腺儿茶酚胺分泌能力。
To assess the relationship among the structure, pungency and thermogenic action, a series of capsaicin analogs with saturated acyl moieties (heptanoyl to eicosanoyl vanillylamide) were synthesized. Pungency of the compounds and the thermogenic action, which was examined by the potential of the compounds (655 nmol/kg, iv) to enhance adrenal catecholamine secretion for 15 min in anesthetized rats, were compared. On the chain length of the acyl moieties of the analogs, nonanoyl to octadecanoyl vanillylamide caused strong adrenal catecholamine secretion, but heptanoyl vanillylamide and eicosanoyl vanillylamide caused weak or no response. Pungent analogs except heptanoyl vanillylamide and non-pungent analogs except eicosanoyl vanillylamide had strong potency to secrete adrenal catecholamine.